Trial reportThe Journal of clinical endocrinology and metabolism2026
Association between polycystic ovary syndrome and pregnancy outcomes in GDM: A secondary analysis of the DiGest trial.
Trial report in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association between polycystic ovary syndrome and pregnancy outcomes in GDM: A secondary analysis of the DiGest trial.The Journal of clinical endocrinology and metabolism · 2026Trial
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
contextPolycystic ovary syndrome (PCOS) is a risk factor for gestational diabetes mellitus (GDM) due to shared pathophysiological associations with insulin resistance and adiposity, and may increase the risk of suboptimal perinatal outcomes in GDM. It is unclear if this excess risk upon outcomes is attributable to PCOS, more severe hyperglycemia, higher maternal BMI or reduced efficacy of dietary interventions.
objectiveTo assess associations of PCOS, dietary intervention and gestational weight loss with maternal and neonatal outcomes in women with GDM. METHODS/
designA secondary analysis from the DiGest double-blind randomized controlled trial. Data on self-reported PCOS status were collected at baseline.
participantsPregnant women with GDM and BMI ≥25 kg/m2 from 8 UK centers (N = 425; 50 with PCOS and 375 without PCOS).
interventionReduced-energy intervention diet (1200 kcal/day) or standard-energy control diet (2000 kcal/day) from enrollment (29 weeks) until delivery.
main outcome measuresPregnancy outcomes, including maternal weight and continuous glucose metrics, physical and dietary data, and infant birthweight and jaundice, were compared between women with and without PCOS using univariate tests and multivariable regression models were applied for adjusted analysis.
resultsWomen with GDM and PCOS had similar baseline characteristics, glycemia, BMI, and pregnancy outcomes compared with women with GDM alone, but their infants had higher rates of neonatal jaundice (24.4% vs 8.9%, P = .002). Outcomes across the dietary interventions were similar in women with and without PCOS.
conclusionIn women with GDM, PCOS was not associated with increased risks for most suboptimal pregnancy outcomes or reduced efficacy of a dietary intervention in this cohort where BMI and glycemia were comparable.
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