Trial reportMolecular nutrition & food research2026
Effect of Glucoraphanin on the Abundance of Nrf2 Regulated Genes Within Circulating Small Extracellular Vesicles: A Pilot Dietary Intervention.
Trial report in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of Glucoraphanin on the Abundance of Nrf2 Regulated Genes Within Circulating Small Extracellular Vesicles: A Pilot Dietary Intervention.Molecular nutrition & food research · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Cruciferous vegetables, including broccoli, are associated with a reduced risk of age-related chronic diseases. Broccoli accumulates glucoraphanin, which is hydrolyzed to sulforaphane, an isothiocyanate, that activates antioxidant genes via nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factor, thereby alleviating age-related diseases. However, sulforaphane's rapid metabolism and excretion raise questions about its efficacy on peripheral tissues. We hypothesize that consumption of a glucoraphanin-rich broccoli soup induces small extracellular vesicles (sEVs) in the systemic circulation, containing Nrf2-induced antioxidant genes, mediating the effects of broccoli consumption on peripheral tissues. Nine adults participated in a two-arm, single-blinded, randomized crossover trial and consumed a glucoraphanin-rich broccoli soup (intervention) and a control soup. Plasma samples were analyzed to quantify abundance of Nrf2 regulated genes within circulating sEVs, while urine samples were analyzed to determine sulforaphane pharmacokinetics. While sulforaphane was detected in urine following the intervention (p < 0.001), there were no differences in the abundance of Nrf2 regulated genes quantified within circulating sEVs. Urinary sulforaphane profiling confirmed the intervention's efficacy; however, the genes examined were unaltered within circulatory sEVs. Given that EV mRNA does not always relate to function, future studies exploring EV proteomics may provide further insights into sulforaphane's underlying mechanisms.
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Registered trials
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