Evidence map›Paper›PMID 41603485›Full record

ArticlePhysiological reports2026

Perivascular adipose tissue from female rats fed a high-fat diet impaired mesenteric artery vasodilation.

Gurneet S Sangha, Ryan M Sapp, Callie M Weber, Donaysia Torbit, Nimisha Rangachar, Anne Barnes, Alisa M Clyne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gurneet S SanghaFischell Department of Bioengineering, University of Maryland College Park, College Park, Maryland, USA.
Ryan M SappFischell Department of Bioengineering, University of Maryland College Park, College Park, Maryland, USA.
Callie M WeberFischell Department of Bioengineering, University of Maryland College Park, College Park, Maryland, USA.
Donaysia TorbitFischell Department of Bioengineering, University of Maryland College Park, College Park, Maryland, USA.
Nimisha RangacharFischell Department of Bioengineering, University of Maryland College Park, College Park, Maryland, USA.
Anne BarnesFischell Department of Bioengineering, University of Maryland College Park, College Park, Maryland, USA.
Alisa M ClyneFischell Department of Bioengineering, University of Maryland College Park, College Park, Maryland, USA.ORCID https://orcid.org/0000-0003-2462-2122

Funding

Vascular Biology Training ProgramT32HL007698 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Rosemary A Kozar, Dudley K. Strickland · 1991 to 2026
$8.7M
Metabolic interactions in the vascular wall: an integrated experimental and computational approachR01HL165193 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI Alisa S Morss Clyne, Ganesh Sriram · 2023 to 2026
$2.9M
The effect of laminar and disturbed flow on endothelial glucose metabolismR01HL140239 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI MORSS CLYNE, ALISA S · 2018 to 2022
$1.9M
Artery-on-a-chip with perivascular adipose tissue for pressure myographyR21EB028466 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI MORSS CLYNE, ALISA S · 2019 to 2020
$415k
American Heart Association Postdoctoral Fellowship 915916American Heart Association Postdoctoral Fellowship 916512HHS | National Institutes of Health (NIH) R01HL140239HHS | National Institutes of Health (NIH) R01HL165193HHS | National Institutes of Health (NIH) R21EB028466National Institutes of Health Postdoctoral Institutional Training Grant 5T32HL007698-26National Science Foundation (NSF) CMMI 1916814National Science Foundation (NSF) DGE 1840340NHLBI NIH HHS R01 HL140239NHLBI NIH HHS R01 HL165193NHLBI NIH HHS T32 HL007698NIBIB NIH HHS R21 EB028466University of Maryland Presidential Postdoctoral Fellowship N/A
6 · The paper itself

Abstract

High-fat diet (HFD) is a cardiovascular risk factor that may disproportionately affect women compared to men. HFD alters perivascular adipose tissue (PVAT), which surrounds arteries and regulates vascular function. This study investigated the sex-specific effects of HFD on PVAT-mediated vascular dysfunction. Male and female Sprague-Dawley rats were fed a normal chow diet (NCD) or HFD for 16 weeks. Thoracic aortic PVAT was isolated, and PVAT adipokine expression and inflammatory markers were measured. We then assessed PVAT-conditioned media effects on vasodilation, endothelial oxidative stress, and endothelial nitric oxide (NO) synthase. PVAT-conditioned media from HFD female but not male rats impaired acetylcholine-induced vasodilation in mesenteric arteries; however, it did not increase oxidative stress or decrease endothelial NO synthase activation in rat endothelial cells in vitro. PVAT from HFD female rats had higher CD68 expression and acetyl-NF-κB/NF-κB ratio than PVAT from NCD female rats. Overall, HFD caused a greater PVAT-induced impairment in vasodilation in female as compared to male rats, which aligns with the heightened cardiovascular risk in women consuming a HFD.

Indexed as

Adipose TissueDiet, High-FatMesenteric ArteriesVasodilationAnimalsAorta, ThoracicEndothelium, VascularFemaleMaleNF-kappa BNitric Oxide Synthase Type IIIOxidative StressRatsRats, Sprague-DawleyNF-kappa BNitric Oxide Synthase Type IIIcardiovascularendothelial dysfunctionhigh‐fat dietinflammationobesityPerivascular adipose tissuesex differencesvasodilation

Identifiers

PMID41603485
PMCPMC12849210

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.