Evidence map›Paper›PMID 41603877›Full record

ArticleAIDS (London, England)2025

Case study of PEPFAR funding cuts on HIV infections and deaths: reversing hard-won gains.

Tsitsi Apollo, Yao-Rui Yeo, Owen Macdonald Mugurungi, Ngwarai Sithole, Isaac Taramusi, Emmanuel Tachiwenyika, Emily Prisca Gwavava, Wanzirai Makoni, Anesu Chimwaza, Kudakwashe Collin Takarinda and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tsitsi ApolloZimbabwe Ministry of Health and Child Care, Harare, Zimbabwe.
Yao-Rui YeoDepartment of Population Health, NYU School of Medicine, New York, NY, USA.
Owen Macdonald MugurungiZimbabwe Ministry of Health and Child Care, Harare, Zimbabwe.
Ngwarai SitholeZimbabwe Ministry of Health and Child Care, Harare, Zimbabwe.
Isaac TaramusiUNAIDS Zimbabwe Country Office.
Emmanuel TachiwenyikaZimbabwe Health Interventions.
Emily Prisca GwavavaPangaea Zimbabwe (PZAT).
Wanzirai MakoniPangaea Zimbabwe (PZAT).
Anesu ChimwazaZimbabwe Ministry of Health and Child Care, Harare, Zimbabwe.
Kudakwashe Collin TakarindaOrganization for Public Health Interventions & Development (OPHID), Harare, Zimbabwe.
Getrude NcubeZimbabwe Ministry of Health and Child Care, Harare, Zimbabwe.
Mellesia JeetooDepartment of Population Health, NYU School of Medicine, New York, NY, USA.
Dyanna CharlesDepartment of Population Health, NYU School of Medicine, New York, NY, USA.
R Scott BraithwaiteDepartment of Population Health, NYU School of Medicine, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using a validated HIV transmission model for Zimbabwe, we simulated January 2025 U.S. President's Plan for AIDS Relief (PEPFAR) funding cuts' impacts on HIV incidence and HIV-related deaths. We found extending funding cuts through 2030 would increase HIV incidence by 78% and add 85 000 infections, producing 25 000 additional HIV-related deaths. However, if PEPFAR reinstated funding within 12  months, much or all of this harm could be offset through more efficient resource allocation, specifically, reallocating funds for oral PrEP towards long-acting PrEP.

Indexed as

HIV InfectionsHumansIncidenceUnited StatesZimbabwe

Identifiers

PMID41603877
PMCPMC12582592

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.