Evidence map›Paper›PMID 41604113›Full record

ArticleGeroScience2026

Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults.

Malte Schmücker, Cathrine Tranberg, Jacob Borch, Mette Killerup Kaae, Michelle Damgaard, Mathias Flensted-Jensen, Ida Blom, Marco Morosetti, Sara Barbarossa, Patrick Orlando and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Malte SchmückerDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark. malte.schmucker@sund.ku.dk.ORCID http://orcid.org/0009-0007-7133-5683
Cathrine TranbergDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.ORCID http://orcid.org/0009-0000-5946-6145
Jacob BorchDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.ORCID http://orcid.org/0009-0008-1854-6876
Mette Killerup KaaeDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.ORCID http://orcid.org/0009-0002-1246-6441
Michelle DamgaardDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.ORCID http://orcid.org/0009-0007-6774-6631
Mathias Flensted-JensenDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5288-9783
Ida BlomDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1602-3031
Marco MorosettiDepartment of Life and Environmental Sciences, Polytechnic University of the Marche, Via Ranieri, 60100, Ancona, Italy.ORCID http://orcid.org/0009-0004-8074-6933
Sara BarbarossaDepartment of Life and Environmental Sciences, Polytechnic University of the Marche, Via Ranieri, 60100, Ancona, Italy.ORCID http://orcid.org/0009-0000-2161-8270
Patrick OrlandoDepartment of Life and Environmental Sciences, Polytechnic University of the Marche, Via Ranieri, 60100, Ancona, Italy.ORCID http://orcid.org/0000-0002-4203-9611
Luca TianoDepartment of Life and Environmental Sciences, Polytechnic University of the Marche, Via Ranieri, 60100, Ancona, Italy.ORCID http://orcid.org/0000-0002-7519-7106
Flemming DelaDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-9970-9535
Jørn Wulff HelgeDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-9724-5423
Steen LarsenDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5170-4337

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial function is important to healthy aging, as it influences energy metabolism, oxidative stress, and physical performance. With age, mitochondrial function and biosynthesis of coenzyme Q10 (CoQ10) may change. CoQ10 serves as a key antioxidant and component of the electron transport system. Supplementation with CoQ10 may help preserve mitochondrial function and support healthy aging. Forty older community-dwelling adults (74 ± 4 years) received either daily oral CoQ10 supplementation (400 mg daily) or a placebo in a 12-week double-blinded, randomized, placebo-controlled design. Before and after the supplementation period, muscle biopsies were obtained. Subsequently, oral glucose tolerance tests (OGTT) and VO

Indexed as

AntioxidantHealthy agingMitochondrial functionReactive oxygen species

Identifiers

PMID41604113

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.