ArticleJournal of magnetic resonance imaging : JMRI2026
Exploring the Dynamics of Ischemia and Reactive Hyperemia With Skeletal Muscle Blood Oxygen Level Dependent MRI in Patients With Peripheral Artery Disease, Age-Matched Controls, and Young Healthy Subjects.
Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Exploring the Dynamics of Ischemia and Reactive Hyperemia With Skeletal Muscle Blood Oxygen Level Dependent MRI in Patients With Peripheral Artery Disease, Age-Matched Controls, and Young Healthy Subjects.Journal of magnetic resonance imaging : JMRI · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundSkeletal muscle blood oxygen level dependent (BOLD) MRI is a technique for assessing vascular function in peripheral limbs. In patients, however, an increased frequency of atypical response patterns has been observed, warranting investigation into its underlying causes. PURPOSE: To explore the dynamics of cuff-induced ischemia and reactive hyperemia with BOLD MRI, focusing on the occurrence, quantification, and interpretation of frequent atypical cuff-induced response patterns. STUDY TYPE: Secondary assessment of prospectively collected datasets. POPULATION: Seventeen peripheral artery disease (PAD) patients (age: 64-80 years, ankle-brachial index (ABI) range: 0.4-0.8), 8 age-matched controls (age: 64-82 years, ABI range: 1-1.2), and 14 young controls (age: 22-39 years). FIELD STRENGTH/SEQUENCE: ASSESSMENT: A transverse slice of the calf was imaged repeatedly during an upper-thigh cuff compression cycle consisting of 1-min baseline, 5-min arterial occlusion (cuff inflated) and 5-min reactive hyperemia (cuff deflated). STATISTICAL TESTS: Non-parametric 2-tailed Wilcoxon rank-sum tests to assess differences between patients and age-matched controls. A p value < 0.05 was considered significant.
resultsAtypical cuff-induced response patterns in PAD patients included a negative cuff-induced transient (42%, soleus) and non-monotonic declines in DATA
conclusionHS EVIDENCE LEVEL: 1. TECHNICAL EFFICACY: 3.
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