Evidence map›Paper›PMID 41604283›Full record

ArticleJournal of neurophysiology2026

Sexual dimorphisms in phrenic long-term facilitation following severe acute intermittent hypoxia.

Brendan J Dougherty, Jessica M L Grittner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brendan J DoughertyDivision of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, Minnesota, United States.ORCID 0000-0002-5995-8948
Jessica M L GrittnerRehabilitation Science Graduate Program, Department of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, Minnesota, United States.ORCID 0000-0002-7806-9564

Funding

Estrogen Receptor Signaling in the Expression of Respiratory Motor PlasticityR01HL146477 · NHLBI · UNIVERSITY OF MINNESOTA · PI Brendan J Dougherty · 2021 to 2026
$3.0M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL146477NHLBI NIH HHS R01 HL146477
6 · The paper itself

Abstract

Rigorous preclinical research in male rodents defined the cellular mechanisms of respiratory neuroplasticity following brief exposures to hypoxia (acute, intermittent hypoxia; AIH). AIH elicits phrenic long-term facilitation (pLTF), a progressive increase in phrenic nerve amplitude over time. Mechanisms to AIH-induced pLTF are complex and variable depending on the severity of hypoxemia during AIH. Moderate AIH (mAIH; [Formula: see text] ∼35-45 mmHg) triggers spinal serotonin receptor activation to induce pLTF expression. More severe AIH (sAIH; [Formula: see text] ∼25-30 mmHg) induces pLTF through an adenosine receptor-dependent pathway. Here we assessed:

Indexed as

acute intermittent hypoxiahypoxianeuroplasticityphrenic long-term facilitationsex differences

Identifiers

PMID41604283
PMCPMC13011792

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.