Evidence map›Paper›PMID 41604489›Full record

ArticleScience advances2026

From Plato to Pareto: Defining the shape of infection's disease space.

Yael Lebel, Avni S Gupta, Victoria Chevée, Uri Alon, David S Schneider

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yael LebelDepartment of Molecular Cell Biology, Weizmann Institute, Rehovot, Israel.ORCID 0009-0000-1865-7543
Avni S GuptaUniversity of Cincinnati Medical Center, Cincinnati, OH 45267, USA.ORCID 0009-0008-6769-8702
Victoria ChevéeUniversity of Cincinnati Medical Center, Cincinnati, OH 45267, USA.ORCID 0009-0002-5936-0302
Uri AlonDepartment of Molecular Cell Biology, Weizmann Institute, Rehovot, Israel.ORCID 0000-0003-1121-5907
David S SchneiderDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-2391-9963

Funding

Using colloborative cross mice to monitor resilience to malariaR21AI145365 · NIAID · STANFORD UNIVERSITY · PI SCHNEIDER, DAVID S. · 2019 to 2020
$434k
NIAID NIH HHS R21 AI145365
6 · The paper itself

Abstract

If the immune system is an interconnected network, then the evolution of an archetype that is ideal for fighting one pathogen should result in trade-offs decreasing its ability to fight others. How many archetypes are there in an immune system? We infected diverse mice with

Indexed as

Host-Pathogen InteractionsMalariaAnimalsCOVID-19HumansMiceMycobacterium tuberculosisPlasmodium chabaudi

Identifiers

PMID41604489
PMCPMC12851040

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.