Evidence map›Paper›PMID 41604552›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Multi-View Biomedical Foundation Models for Molecule-Target and Property Prediction.

Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán-Sáenz, Daniel E Platt, Timothy H Rumbell and 8 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Parthasarathy SuryanarayananIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0000-0002-8619-2976
Yunguang QiuCleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-5094-0936
Shreyans SethiIBM Research - Almaden, 650 Harry Rd, San Jose, CA, USA.ORCID https://orcid.org/0009-0002-0577-2029
Diwakar MahajanIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0000-0001-9791-2038
Hongyang LiIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0000-0002-7902-4157
Yuxin YangCleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-8316-7636
Elif EyigozIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0000-0002-6700-7958
Aldo Guzmán-SáenzIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0000-0003-2725-621X
Daniel E PlattIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0000-0002-6826-928X
Timothy H RumbellIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0000-0003-4028-6464
Kenney NgIBM Research, 314 Main St, Cambridge, MA, USA.ORCID https://orcid.org/0000-0003-0792-070X
Sanjoy DeyIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0000-0002-8413-9573
Myson BurchIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0009-0008-4278-3310
Bum Chul KwonIBM Research, 314 Main St, Cambridge, MA, USA.ORCID https://orcid.org/0000-0002-9391-6274
Pablo MeyerIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0000-0001-5281-4661
Feixiong ChengCleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-1736-2847
Jianying HuIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0000-0001-7753-886X
Joseph A MorroneIBM TJ Watson Research Center, 1101 Kitchawan Rd., Yorktown Heights, NY, USA.ORCID https://orcid.org/0000-0001-8550-4854

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular foundation models hold promise to provide accurate predictions for a large and diverse set of downstream tasks in bio-medical research. Quality molecular representations are key and foundation model development has typically focused on a single representation or molecular view, which may have strengths or weaknesses on a given task. We develop Multi-view Molecular Embedding with Late Fusion (MMELON), an approach that integrates pre-trained graph, image and text foundation models and may be readily extended to additional views and models. The multi-view model performs robustly and is validated on over 120 tasks, including molecular solubility, ADME properties, and activity against G Protein-Coupled receptors (GPCRs). The GPCR model array is leveraged to perform a virtual screen in search of ligands binding to Alzheimer's disease related GPCRs. We identify a number of such targets and employ the multi-view model to select strong binders from a compound screen. Predictions are validated through structure-based modeling and identification of key binding motifs.

Indexed as

Alzheimer DiseaseDrug DiscoveryModels, MolecularReceptors, G-Protein-CoupledHumansLigandsLigandsReceptors, G-Protein-CoupledAlzheimer's diseasefoundation modelsmolecular property predictionvirtual screening

Identifiers

PMID41604552
PMCPMC12970179

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.