Evidence map›Paper›PMID 41605950›Full record

ArticleScientific data2026

Transformer-based relation extraction and concept normalization using an annotated clinical trials corpus.

Leonardo Campillos-Llanos, Ana Valverde-Mateos, Adrián Capllonch-Carrión, David González-Quevedo, María Rosa López-Urbán, María Soledad Hernando-Tundidor, Sofía Zakhir-Puig, Jónathan Heras

Abstract readDataset
In one paragraph

Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leonardo Campillos-LlanosILLA, CCHS CSIC, Madrid, 28037, Spain. leonardo.campillos@csic.es.ORCID http://orcid.org/0000-0003-3040-1756
Ana Valverde-MateosUTM RANME, Madrid, 28013, Spain.ORCID http://orcid.org/0000-0003-1610-0770
Adrián Capllonch-CarriónCSM Retiro, Hospital Gregorio Marañón, Madrid, 28009, Spain.ORCID http://orcid.org/0000-0001-9593-8621
David González-QuevedoHospital Regional Universitario de Málaga, Málaga, 29010, Spain.ORCID http://orcid.org/0000-0001-8881-4196
María Rosa López-UrbánHospital Gregorio Marañón, Madrid, 28009, Spain.
María Soledad Hernando-TundidorInformation Processing Unit, CCHS CSIC, Madrid, 28037, Spain.ORCID http://orcid.org/0000-0002-2869-4652
Sofía Zakhir-PuigIULMA, Universitat de València, Valencia, 46010, Spain.ORCID http://orcid.org/0000-0001-5919-5859
Jónathan HerasDepartamento de Matemáticas y Computación, Universidad de La Rioja, Logroño, 26004, Spain.ORCID http://orcid.org/0000-0003-4775-1306

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Healthcare professionals manually review electronic health records to select patients who meet eligibility criteria of clinical trials. Natural language processing offers a complement for this task, although few initiatives exist in Spanish. We present version 3 of the CT-EBM-SP corpus of 1200 clinical trials (292173 tokens), annotated with 23 entity types and 18 relation types, covering Unified Medical Language System (UMLS) semantic groups, drug-related information, temporal data, and negation/speculation. We encoded 11 attributes (e.g., event temporality and experiencer status) and normalized entities to UMLS Concept Unique Identifiers. The corpus contains 87037 entities, including nested and discontinuous entities, 16597 attributes and 68206 relationships. Inter-annotator agreement (IAA) achieved average F1 values of 0.861 (entities), 0.810 (attributes), and 0.791 (relations). 81.75% of entities were normalized (IAA: F1 = 0.966). We benchmarked this dataset by fine-tuning Transformer models for relation extraction (RE) and medical concept normalization (MCN). In RE, the average F1 ranged from 0.858 to 0.879, and for MCN, the accuracy at rank 1 was 0.896. The corpus and models are publicly available.

Indexed as

Clinical Trials as TopicElectronic Health RecordsNatural Language ProcessingHumansUnified Medical Language System

Identifiers

PMID41605950
PMCPMC12921031

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.