ArticleNature2026
Intestinal macrophages modulate synucleinopathy along the gut-brain axis.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Review
- TLR2 Regulates α-Synuclein Phosphorylation and Release in an Enteroendocrine Cell Model.Molecular neurobiology · 2026Article
- Tissue-Resident Macrophages: Linking Physiology and Inflammation in Infection.Clinical reviews in allergy & immunology · 2026Review
- Review
- Self-assembled structures as a material basis for indirect pharmacology in Traditional Chinese Medicine.Chinese medicine · 2026Review
- Intestinal muscularis in health and disease.Communications biology · 2026Review
- CSF1R-related leukoencephalopathy: experimental models and potential for treatment.Disease models & mechanisms · 2026Review
- Csf1r-mediated depletion of myeloid cells prevents dopaminergic neuron loss during chronic colitis.Journal of neuroinflammation · 2026Article
- Knockout of α-Synuclein Is Associated with Depression-like Behaviors by Altered Excitability of Medial Prefrontal Cortex Neurons in Mice.International journal of molecular sciences · 2026Article
- Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Article
- Microbiota-Gut-Brain Axis in Neurodegenerative Diseases: The Role of Bacterial Amyloids.Cellular and molecular gastroenterology and hepatology · 2026Review
- Intestinal stem cells as innate immune sentinels: coupling environmental sensing to epithelial adaptation.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Sebastiaan De SchepperUK Dementia Research Institute, University College London, London, UK. sebastiaan.deschepper@uantwerpen.be.ORCID 0000-0003-0640-2417
Viktoras KonstantellosUK Dementia Research Institute, University College London, London, UK.
James A Conway *UK Dementia Research Institute, University College London, London, UK.ORCID 0000-0002-6044-4602
Dimitra Sokolova *UK Dementia Research Institute, University College London, London, UK.
Ludovica ZaccagniniUK Dementia Research Institute, University College London, London, UK.
Matthew V CowleyDivision of Infection and Immunity, University College London, London, UK.ORCID 0000-0002-5258-8024
Annerieke SierksmaVIB Center for Brain and Disease Research, Leuven, Belgium.ORCID 0000-0001-9233-972X
Maria YudinaUK Dementia Research Institute, University College London, London, UK.
Marisa EdmondsUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0002-1918-110X
Daria GavriouchkinaUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0002-7488-5898
Bethany GearyMedical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Amber WallisUK Dementia Research Institute, University College London, London, UK.
Meral CelikagUK Dementia Research Institute, University College London, London, UK.
Zeynep BaykamUK Dementia Research Institute, University College London, London, UK.
Mónica Vara-PérezBrain and Systems Immunology Laboratory, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0001-6196-4696
Gerard CrowleyUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0003-0436-1332
Fabian Tobias HagerInstitute of Molecular Medicine, RWTH Aachen University, Aachen, Germany.
Mitchell BijnenInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-2781-8702
David PosnerMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.
Kelvin LukDepartment of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6591-6269
Vuk CerovicInstitute of Molecular Medicine, RWTH Aachen University, Aachen, Germany.ORCID 0000-0003-1392-0669
Menna ClatworthyMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3340-9828
Elizabeth J VidelockCenter for Inflammatory Bowel Diseases, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0000-0001-8460-6189
Zane JaunmuktaneDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0001-7738-8881
Kiavash MovahediBrain and Systems Immunology Laboratory, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0002-0826-4399
Melanie GreterInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-7220-5369
Benny ChainDivision of Infection and Immunity, University College London, London, UK.ORCID 0000-0002-7417-3970
Dario R AlessiMedical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.ORCID 0000-0002-2140-9185
Soyon HongUK Dementia Research Institute, University College London, London, UK. soyon.hong@ucl.ac.uk.ORCID 0000-0002-5744-4871
Tim BartelsUK Dementia Research Institute, University College London, London, UK. t.bartels@ucl.ac.uk.ORCID 0000-0002-4071-5612
Funding
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5MUtilization of proteomics and lipidomics to identify modifiers of LBDU54NS110435 · NINDS · MAYO CLINIC JACKSONVILLE · PI MCLEAN, PAMELA J · 2019 to 2023
$14.5MNational Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8MMechanisms of Synaptic Dysfunction in Parkinson s and Other Synuclein-Linked DiseasesR01NS078165 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI Jennifer Rebecca Morgan · 2012 to 2026
$5.5MElucidating the Biological Differences Between Distinct Fibrillar and Non-Fibrillar Alpha-Synuclein Inclusions in Human Stem-Cell ModelsR01NS109209 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KHURANA, VIKRAM · 2020 to 2024
$4.5MHow Serine-129 Phosphorylation Status Affects the Spreading of α-Synuclein Pathology in Vivo: a Study in Knock-in AnimalsR01NS133979 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Ulf Dettmer, Nagendran Ramalingam · 2026 to 2026
$724kCollaborative PairsNational Brain and Tissue Resource for Parkinsons Disease and Related DisordersNIA NIH HHS P30 AG019610NINDS NIH HHS R01 NS078165NINDS NIH HHS R01 NS109209NINDS NIH HHS R01 NS133979NINDS NIH HHS U24 NS072026NINDS NIH HHS U54 NS110435Swiss National Science FoundationUK Dementia Research InstituteUK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UKWellcome Trust
Abstract
Emerging evidence suggests that Parkinson's disease (PD) may have its origin in the enteric nervous system (ENS), from where α-synuclein (αS) pathology spreads to the brain
Indexed as
Brain-Gut AxisEnteric Nervous SystemMacrophagesParkinson Diseasealpha-SynucleinAnimalsBrainDisease Models, AnimalFemaleHumansIntestinesLysosomesMaleMiceSynucleinopathiesT-Lymphocytesalpha-Synuclein
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.