Evidence map›Paper›PMID 41606392›Full record

ArticleArchives of toxicology2026

Metabolic and antioxidant imbalance in Sertoli cells induced by tributyltin exposure is accompanied by Sirt3 downregulation.

L Rato, A Bastos, L Machado, E Carreiro, M G Alves, P F Oliveira, B M Silva, A C A Sousa

Abstract read
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In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

L RatoUniversidade de Évora, Comprehensive Health Research Centre (CHRC), Escola de Saúde e Desenvolvimento Humano, Departamento de Ciências Médicas e da Saúde, Évora, Portugal. luis.pedro.rato@uevora.pt.ORCID 0000-0002-7796-2051
A BastosUniversity of Beira Interior, 6201-001, Covilhã, Portugal.
L MachadoDepartamento de Biologia, Escola de Ciências e Tecnologia, Universidade de Évora, Évora, Portugal.
E CarreiroUniversidade de Évora, IIFA - LAQV-REQUIMTE - Polo Universidade de Évora, Rua Romão Ramalho, nº 59, 7000-671, Évora, Portugal.ORCID 0000-0001-8117-7737
M G AlvesiBiMED-Institute of Biomedicine and Department of Medical Science, University of Aveiro, 3810-193, Aveiro, Portugal.ORCID 0000-0001-7635-783X
P F OliveiraLAQV-REQUIMTE and Department of Chemistry, Campus Universitario de Santiago, University of Aveiro, 3810-193, Aveiro, Portugal.ORCID 0000-0002-4989-5699
B M SilvaUniversity of Beira Interior, 6201-001, Covilhã, Portugal.ORCID 0000-0002-5610-8024
A C A SousaUniversidade de Évora, Comprehensive Health Research Centre (CHRC), Escola de Saúde e Desenvolvimento Humano, Departamento de Ciências Médicas e da Saúde , Évora, Portugal.ORCID 0000-0001-6424-7414

Funding

Fundação para a Ciência e a Tecnologia CEECINST/00026/2018 and UIDP/00215/2020Fundação para a Ciência e a Tecnologia UID/04923 - Comprehensive Health Research CentreFundação para a Ciência e a Tecnologia UIDB/04501/2020 - DOI 10.54499/UIDB/04501/2020 and UIDP/04501/2020 - DOI 10.54499/UIDP/04501/2020Fundação para a Ciência e a Tecnologia UIDB/50006/2020 and UIDP/50006/2020
6 · The paper itself

Abstract

Tributyltin (TBT), an environmental obesogen and endocrine disruptor that can accumulate in the food chain, impairs Sertoli cell (SC) function, yet its impact on the redox-regulating SIRT1/PGC-1α/SIRT3 axis remains uncharacterized. This study elucidates TBT-induced disruptions in SC redox homeostasis via this molecular axis. Primary cultures of juvenile rat SCs were exposed to environmentally relevant TBT concentrations (0.1 nM, 10 nM) for 24 h. Metabolic fluxes were quantified via

Indexed as

AntioxidantsEndocrine DisruptorsSertoli CellsSirtuin 3Trialkyltin CompoundsAnimalsCells, CulturedDown-RegulationMaleOxidation-ReductionOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRatsSirtuin 1SirtuinsAntioxidantsEndocrine DisruptorsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, ratSirt1 protein, ratSIRT3 protein, ratSirtuin 1Sirtuin 3SirtuinsTrialkyltin CompoundstributyltinAntioxidant capacityEndocrine disruptorsMale fertilityObesogens

Identifiers

PMID41606392

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.