Evidence map›Paper›PMID 41606459›Full record

ArticleThe journal of headache and pain2026

Dorsal root ganglion neuromodulation restores accumbal gate to inhibit mechanical allodynia.

Xuelian Li, Hongyi Wang, Jiahui Ma, Zhenxing Li, Kuankuan Li, Xuebin Yan, Dong Huang, Xing Liu, Yuzhao Huang, Rong Hu and 1 more

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Article in The journal of headache and pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Xuelian LiDepartment of Pain, the Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, 410013, China.
Hongyi WangDepartment of Pain, the Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, 410013, China.
Jiahui MaDepartment of Pain, the Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, 410013, China.
Zhenxing LiDepartment of Pain, the Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, 410013, China.
Kuankuan LiDepartment of Pain, the Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, 410013, China.
Xuebin YanDepartment of Pain, the Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, 410013, China.
Dong HuangDepartment of Pain, the Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, 410013, China.
Xing LiuDepartment of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Yuzhao HuangDepartment of Orthopaedics, the Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Rong HuDepartment of Pain, the Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, 410013, China. 16902407@qq.com.
Haocheng ZhouDepartment of Pain, the Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, 410013, China. haocheng.zhou@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMechanical allodynia refers to a hypersensitive status in response to innoxious stimuli caused by neuropathic pain. A therapeutic strategy to reverse the sensory impairment is neuromodulation treatment selectively targeting the dorsal root ganglion. However, the supra-spinal mechanism of neuromodulation therapy remains elusive.

methodsBy combination of the multiple-channel neurophysiology recording and cellular manipulation in freely moving rats, we investigated the gate function of nucleus accumbens in control of nociceptive inputs, and its role in pulsed-radiofrequency neuromodulation therapy for neuropathic pain, using a clinically relevant neuromodulation parameter.

resultsWe initially identified a gaining representation of the nucleus accumbens in response to nociceptive (pinprick), but not innoxious inputs (4 g Von Frey filament) in naïve rats. In neuropathic pain condition, the gate function was disrupted to drive an enhancement of accumbal activity during mechanical allodynia behavior. Pulsed radiofrequency neuromodulation of dorsal root ganglion was utilized to reverse pain hypersensitivity and accumbal homeostasis. Furthermore, we found that the accumbal gaining was not only a dynamic integration of painful signals, but also to serve as a gate of nociceptive perception required for neuromodulation therapy. In addition, the supra-spinal modulation effect on allodynic phenotype was imitated through optogenetic activation of the accumbal terminals of the spinal cord projections.

conclusionsOur data indicates that the accumbal gate is essential for integration and control of sensory inputs, potentially acting as one neuromodulatory target to reverse pain sensitization.

Indexed as

Ganglia, SpinalHyperalgesiaNeuralgiaNucleus AccumbensPulsed Radiofrequency TreatmentAnimalsMaleRatsRats, Sprague-DawleyDorsal root ganglionMechanical allodyniaNeuromodulationNeuropathic painNoxiousNucleus accumbensSpinal

Identifiers

PMID41606459
PMCPMC12895707

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.