ArticleBMC research notes2026
Lipidomic signatures in lung adenocarcinoma and spontaneous pneumothorax tissues associated with heated tobacco use: a pilot study.
Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Cigarette smoke induces FASN-dependent fatty acid metabolic rewiring to drive bladder cancer progression.Cancer letters · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCigarette smoking alters lipid metabolism in the lung, but the effects of heated tobacco products (HTPs) remain unclear. We aimed to investigate potential lipidomic alterations in lung and lung cancer tissues associated with HTP exposure.
resultsWe performed lipidomic analysis on specimens from lung adenocarcinoma (LAD) and spontaneous pneumothorax patients. Frozen cancer and adjacent normal lung tissues from LAD cases and lung tissues from pneumothorax cases were analyzed using liquid chromatography-tandem mass spectrometry. Relative intensities of 24 lipid classes were compared among the HTP-user, cigarette-smoker, and never-smoker groups (two cases for each group). In LAD cases, the HTP-user group exhibited high levels of acylcarnitine (AcCa), coenzyme Q10 (CoQ10), triglyceride (TG), and phosphatidylethanolamine in cancer tissue, and CoQ10, TG and monohexosylceramide in normal lung tissue. Cholesteryl ester and cholesterol were consistently low in both cancer and normal lung tissues, while multiple lysophospholipids (lysosphingomyelin, lysophosphatidylethanolamine, lysophosphatidylcholine) and phosphatidylserine were low in normal lung tissue. In pneumothorax cases, CoQ10 was high and AcCa low in HTP-users, though similar patterns were observed in cigarette-smokers. This exploratory pilot study suggests that HTP use may induce oxidative stress-driven metabolic reprogramming, membrane remodeling, and stress-adaptive responses in lung and lung cancer tissues.
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