ArticleCell & bioscience2026
In vitro mimicking of humanized cardiogenesis under porcine condition.
Article in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
backgroundOne promising strategy to generate humanized organs is through embryo complementation by injecting human pluripotent stem cells (PSCs) into gene-edited porcine embryos. This strategy is predicated on how human cells adapt to a porcine environment, which has a body temperature of 38.5 °C, much higher than that of the human body.
resultsHere, we present an in vitro model to address this problem by coculturing human and porcine induced PSCs at 38.5 °C and inducing them to generate cardiomyocytes. We show that co-cultured human cells can differentiate into myocardial features with the help of porcine cells at an enhanced differentiation rate. Mechanistically, we show that co-cultured human cells respond to elevated temperature by activating a stress response with the PI3K-Akt-mTOR signaling pathway activated. Moreover, a model mimicking embryo complementation by knocking out MYH6 in pig PSCs reveals the potential risk of porcine cells leaking into human-derived tissues.
conclusionsTogether, our studies present a novel model system to evaluate human and porcine cell co-differentiation that may guide the planning of in vivo experiments.
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