Evidence map›Paper›PMID 41607082›Full record

ArticleAnnals of medicine2026

Dexmedetomidine nasal spray for patients undergoing endoscopic retrograde cholangiopancreatography: protocol for a randomized controlled trial.

Min-Yuan Zhuang, Li-Na Xu, Jun Lv, Lin-Lin Liu, Yong-da Lu, Fu-Hai Ji, Nazneen Sudhan, Lei Huang, Ke Peng

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Min-Yuan ZhuangDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Li-Na XuDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Jun LvDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Lin-Lin LiuDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yong-da LuDepartment of Gastroenterology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Fu-Hai JiDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0001-6649-665X
Nazneen SudhanAnesthesia and Critical Care, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, London, UK.
Lei HuangDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Ke PengDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0003-2879-1759

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEndoscopic retrograde cholangiopancreatography (ERCP) is associated with significant discomfort and necessitates adequate sedation. This study aims to determine the effect of dexmedetomidine nasal spray adjunct to propofol sedation for patients undergoing ERCP procedures. PATIENTS AND

methodsThis randomized, double-blind, placebo-controlled trial will be conducted at a tertiary teaching hospital in eastern China. Approximately 15 min before sedation, 160 adult patients will be randomly assigned (1:1) to either the dexmedetomidine group (dexmedetomidine nasal spray; DISCUSSION: We anticipate that preoperative dexmedetomidine nasal spray will decrease total propofol requirements, reduce sedation-related adverse events, and enhance recovery for patients undergoing ERCP.

trial registrationChinese Clinical Trial Registry (ChiCTR2400093656) on December 10, 2024.

Indexed as

Cholangiopancreatography, Endoscopic RetrogradeDexmedetomidineHypnotics and SedativesProcedural SedationAdministration, IntranasalAdultAgedChinaDouble-Blind MethodFemaleHumansMaleMiddle AgedNasal SpraysPropofolRandomized Controlled Trials as TopicDexmedetomidineHypnotics and SedativesNasal SpraysPropofolDexmedetomidineendoscopic retrograde cholangiopancreatographynasal spraypropofol sedationtarget-controlled infusion

Identifiers

PMID41607082
PMCPMC12863067

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.