ArticleInternational journal of rheumatic diseases2026
Identification of SDC1 as a Key Regulator and Therapeutic Target in Rheumatoid Arthritis via JAK2-STAT3 Pathway.
Article in International journal of rheumatic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Identification of SDC1 as a Key Regulator and Therapeutic Target in Rheumatoid Arthritis via JAK2-STAT3 Pathway.International journal of rheumatic diseases · 2026Article
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7 authors.
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Abstract
introductionRheumatoid arthritis (RA) is a chronic autoimmune disorder with unclear molecular mechanisms, complicating early diagnosis and treatment. This study aimed to identify hub genes and pathways driving RA pathogenesis and assess their therapeutic potential.
methodsGene expression datasets related to RA were retrieved from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified and analyzed by functional enrichment and protein-protein interaction network construction. Machine learning approaches, including LASSO regression, random forest, and SVM-RFE, were used to screen hub genes. Pathway associations were explored using Gene Set Enrichment Analysis (GSEA). Experimental validation was performed in collagen-induced arthritis (CIA) rat models and MH7A synovial fibroblast cells through Western blot and functional assays.
resultsA total of 106 DEGs were identified in RA synovial tissues, including 76 upregulated and 30 downregulated genes. Enrichment analyses revealed involvement in cytokine-cytokine receptor interaction, lymphocyte-mediated immunity, and immunoglobulin complexes. SDC1 emerged as a key hub gene across all three machine learning methods. GSEA indicated its significant correlation with the JAK-STAT pathway. In CIA rats, SDC1 expression was markedly elevated alongside p-JAK2 and p-STAT3 levels. Silencing SDC1 in MH7A cells reduced cell proliferation, decreased p-JAK2 and p-STAT3 expression, and promoted apoptosis.
conclusionsThis study identifies SDC1 as a central hub gene in RA pathogenesis through activation of the JAK2-STAT3 signaling pathway. These findings highlight SDC1 as a potential biomarker for early diagnosis and a promising target for therapeutic intervention, providing new insights into RA management.
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