ArticleWorld journal of psychiatry2026
Abnormal regional spontaneous brain activity in major depressive disorder with obesity comorbidity: A resting-state functional magnetic resonance imaging study.
Article in World journal of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMajor depressive disorder (MDD) and obesity (OB) are bidirectionally comorbid conditions with common neurobiological underpinnings. However, the neurocognitive mechanisms of their comorbidity remain poorly understood.
aimTo examine regional abnormalities in spontaneous brain activity among patients with MDD-OB comorbidity.
methodsThis study adopted a regional homogeneity (ReHo) analysis of resting-state functional magnetic resonance imaging. The study included 149 hospital patients divided into four groups: Patients experiencing their first episode of drug-naive MDD with OB, patients with MDD without OB, and age- and sex-matched healthy individuals with and without OB. Whole-brain ReHo analysis was conducted using SPM12 software and RESTplus toolkits, with group comparisons
resultsANOVA revealed significant whole-brain ReHo differences among the four groups in four key regions: The left middle temporal gyrus (MTG.L), right cuneus, left precuneus, and left thalamus. Post-hoc analyses confirmed pairwise differences between all groups across these regions (
conclusionOur findings provide novel evidence for the neuroadaptive mechanisms underlying the MDD-OB comorbidity. Further validation could lead to personalized interventions targeting MTG.L hyperactivity and targeting healthy food cues.
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