ArticleWorld journal of psychiatry2026
Preoperative butyrylcholinesterase activity and risk of postoperative delirium: A meta-analysis.
Article in World journal of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
backgroundPostoperative delirium (POD) is a common and serious complication in surgical patients, particularly older adults. Alterations in cholinergic function have been implicated in its pathophysiology.
aimTo evaluate the association between preoperative serum cholinesterase (ChE) activity-specifically butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE)-and the risk of POD in adult surgical patients in a meta-analysis.
methodsA systematic search was conducted in PubMed, EMBASE, and Web of Science up to March 28, 2025 for studies reporting preoperative serum BuChE or AChE activity in relation to subsequent POD incidence. Standardized mean differences (SMDs) and odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using random-effects models. Subgroup and sensitivity analyses were performed based on follow-up duration and analytic models.
resultsThirteen studies (
conclusionLower preoperative serum BuChE activity is associated with an increased risk of POD in adults undergoing surgery. BuChE activity may serve as a potential preoperative biomarker for POD risk stratification.
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