Evidence map›Paper›PMID 41607445›Full record

ReviewWorld journal of psychiatry2026

Non-right-handedness and psychiatric disorders: A synthesis of epidemiological, genetic, and neurobiological evidence.

Qing-Qing Wang, Zhong-Sheng Sun, Jie-Si Wang

Abstract readReview
In one paragraph

Review in World journal of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qing-Qing WangState Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
Zhong-Sheng SunInstitute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Jie-Si WangState Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China. wangjs@psych.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-right-handedness (NRH), encompassing left-handedness and mixed-handedness, has been frequently reported at elevated rates in individuals with various psychiatric disorders. The consistency of this association across multiple conditions and its underlying mechanisms is the subject of ongoing investigation. This review synthesized current evidence to explore the association between NRH and psychiatric disorders from epidemiological, genetic, and neurobiological perspectives. We systematically identified and appraised relevant literature investigating NRH prevalence in psychiatric populations and potential explanatory mechanisms. Epidemiological evidence indicates an elevated prevalence of NRH, particularly within neurodevelopmental disorders. Potential contributing mechanisms identified include early developmental disruptions, shared genetic predispositions, and atypical patterns of brain lateralization. While the association between NRH and psychiatric conditions, especially neurodevelopmental disorders, is evident, the causal pathways and relative contributions of identified mechanisms are complex and debated. This review highlighted key areas requiring further research to elucidate these relationships.

Indexed as

Brain lateralization/asymmetryEarly developmental disruptionHandednessInterhemispheric connectivityNeurodevelopmental disordersPsychiatric disorder

Identifiers

PMID41607445
PMCPMC12836242

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.