ArticleFrontiers in endocrinology2025
Gender-specific associations between neutrophil levels and refracture risks: a retrospective cohort study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Osteoporotic fractures (OPFs) significantly impact global health, predominantly affecting individuals over 50 years old. Furthermore, it has high incidence and refracture rates. Currently, the association between neutrophil (NEU) levels and the risk of recurrent fractures is still undetermined. Therefore, this study investigated the association between NEU levels at hospital admission and recurrent fracture risk in OPF patients. Methods: This retrospective cohort study analyzed 2,474 OPF patients who underwent surgical intervention at the Affiliated Kunshan Hospital of Jiangsu University between 2018 and 2023. The data were acquired from the hospital's Osteoporotic Fracture Registration System. Patients' NEUs were measured at admission, and they were followed up for recurrent fractures. Statistical assessments were carried out Results: The results showed a significant sigmoidal (non-linear) relationship between the risk of recurrent fractures and NEU counts in male patients. Furthermore, NEU levels ranged between 4.4 - 8.5 ×10 Conclusions: This study indicated a significant sigmoidal correlation between NEU levels and refracture risk in male OPF patients, ranging from 4.4 to 8.5 ×10
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