ArticleFrontiers in oncology2025
Dynamic changes in prognostic nutritional index and systemic immune-inflammation index predict survival following debulking surgery in ovarian cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic effect of the preoperative albumin-to-globulin ratio bladder cancer: a meta-analysis.Frontiers in medicine · 2026Pooled it
- Preoperative Systemic Inflammatory Indices and Their Association with Tumor Burden and Surgical Outcomes in High-Grade Serous Ovarian Cancer.Diseases (Basel, Switzerland) · 2026Article
- Risk stratification of postoperative enteral feeding intolerance using explainable machine learning in oral cancer free flap reconstruction.Frontiers in nutrition · 2026Article
- Systemic immune-inflammation index combined with blood urea nitrogen to albumin ratio predicts 28-day mortality in sepsis: a retrospective cohort study.Frontiers in physiology · 2026Article
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5 authors.
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Abstract
Background: Ovarian cancer remains the most lethal gynecologic malignancy. Increasing evidence suggests that host immunonutritional status and systemic inflammation-captured by the Prognostic Nutritional Index (PNI) and the Systemic Immune-Inflammation Index (SII)-influence postoperative recovery and survival outcomes. Methods: This retrospective study included 78 patients who underwent primary debulking surgery for epithelial ovarian cancer. Preoperative and 6-hour postoperative PNI and SII values were calculated, and ΔPNI was defined as the postoperative-preoperative difference. Associations with postoperative inflammatory markers and overall survival (OS) were evaluated using Spearman correlation, Kaplan-Meier analysis, and Cox regression. Results: Postoperative PNI decreased significantly (49.3 → 34.1; p < 0.001), and SII increased markedly (964.7 → 4003.2; p < 0.001). Lower postoperative PNI and higher preoperative SII were associated with greater postoperative inflammatory response. In multivariate analysis, higher postoperative PNI independently predicted improved OS (HR 0.94, 95% CI 0.89-0.99; p = 0.021), while higher preoperative SII independently predicted worse OS (HR 1.18, 95% CI 1.01-1.36; p = 0.037). ΔPNI and postoperative SII were not independently prognostic. Conclusion: Postoperative PNI and preoperative SII provide complementary and independent prognostic information in patients undergoing primary debulking surgery for ovarian cancer. ΔPNI reflects acute immunonutritional stress but does not independently predict survival. Given their accessibility and modifiability, these indices may support perioperative risk stratification and represent potential targets for future interventional studies.
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