ReviewFrontiers in genetics2026
Chromatin remodeling and epigenetic regulation in chronic kidney disease.
Review in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Role of Epigenetics in Corneal Fibrosis.Epigenomes · 2026Review
- Developmental origins and environmental determinants of cardiovascular-kidney-metabolic syndrome: A pediatric precision prevention perspective.Biomedical journal · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The progression of chronic kidney disease (CKD) stems from persistent maladaptive alterations in renal cellular gene expression, processes governed by dynamic epigenetic regulation. The dynamic regulation of chromatin encompasses structural changes, condensation, altered accessibility, and ATP-dependent remodeling, playing a pivotal role in CKD progression. Dysregulation of these processes is increasingly implicated in key pathogenic events such as fibroblast activation and inflammatory responses. Recent advances in multi-omics approaches have provided crucial insights into the composition, mechanisms, and dysregulation of chromatin states within diseased kidneys. In this review, we summarize the current understanding of chromatin dynamics and remodeling in CKD, emphasizing their role in disease progression and their interplay with other epigenetic layers. We further discuss how these mechanisms contribute to establishing pathogenic transcriptional memory and highlight emerging therapeutic opportunities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.