Evidence map›Paper›PMID 41607800›Full record

ArticleFrontiers in immunology2025

Impact of low-grade inflammation on neurological outcomes in patients with acute pontine infarction: a retrospective cohort study.

Junyu Zhu, Hai Zhou, Jierong Mo, Tianen Zhou, Jun Jiang, Zhiwen Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junyu Zhu *Department of Emergency, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Guangdong, China.
Hai Zhou *Central Laboratory, Yunfu People's Hospital, Yunfu, Guangdong, China.
Jierong Mo *Department of Emergency, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Guangdong, China.
Tianen ZhouDepartment of Emergency, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Guangdong, China.
Jun JiangDepartment of Emergency, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Guangdong, China.
Zhiwen ZhangDepartment of Medical Affairs, The First People's Hospital of Foshan, (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute pontine infarction significantly impacts neurological function and prognosis. Recent studies suggest that low-grade inflammation (LGI) may play a critical role in influencing recovery outcomes. However, the relationship between LGI and neurological prognosis in acute pontine infarction remains underexplored. Objectives: This study aims to investigate the correlation between LGI and neurological outcomes in patients with acute pontine infarction over 90 days post-stroke. Methods: A retrospective cohort study was conducted involving 502 patients diagnosed with acute pontine infarction at The First People's Hospital of Foshan between January 1, 2015, and July 14, 2022. Clinical data, inflammatory markers (CRP, WBC, NLR, PLT), and neurological function assessed via NIHSS scores were collected and analyzed. Results: Elevated levels of inflammatory markers were significantly associated with poorer neurological outcomes. The LGI scores correlated positively with NIHSS scores at discharge and 90 days post-stroke, indicating that higher LGI is predictive of impaired recovery. Conclusion: This study demonstrates that low-grade inflammation is an important predictor of neurological outcomes in acute pontine infarction patients. Incorporating LGI assessments into clinical practice may enhance prognostic accuracy and inform treatment strategies.

Indexed as

Brain Stem InfarctionsInflammationPonsAgedBiomarkersFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesBiomarkersacute pontine infarctioninflammatory markerslow-grade inflammationneurological outcomesprognosis

Identifiers

PMID41607800
PMCPMC12835896

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.