Evidence map›Paper›PMID 41607829›Full record

ArticleWorld journal of transplantation2026

Incidence, risk factors and survival outcomes of post-transplant tertiary hyperparathyroidism in kidney recipients.

Shmuel Hanson, Jorge Menendez Lorenzo, Chukwuma Austin Chukwu, Anirudh Rao, Rachel Middleton, Philip A Kalra

Abstract read
In one paragraph

Article in World journal of transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shmuel HansonDepartment of Medicine, University of Manchester, Manchester M13 9PL, United Kingdom.
Jorge Menendez LorenzoDepartment of Medicine, University of Manchester, Manchester M13 9PL, United Kingdom.
Chukwuma Austin ChukwuDepartment of Nephrology, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, Mersey Side, United Kingdom.
Anirudh RaoDepartment of Nephrology, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, Mersey Side, United Kingdom.
Rachel MiddletonFaculty of Biology, Medicine and Health, Department of Cardiovascular Medicine, University of Manchester, Manchester M13 9PL, United Kingdom.
Philip A KalraFaculty of Biology, Medicine and Health, Department of Cardiovascular Medicine, University of Manchester, Manchester M13 9PL, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-transplant tertiary hyperparathyroidism (PT-tHPT) is a well-recognized complication following kidney transplantation, characterized by persistent excessive secretion of parathyroid hormone (PTH) despite improved renal function. It is potentially associated with an increased risk of cardiovascular events, renal osteodystrophy, pathologic fractures, graft loss, and mortality.

aimTo evaluate the incidence, risk factors, and outcomes of PT-tHPT amongst kidney transplant recipients.

methodsA total of 887 transplant recipients who underwent transplantation between 2000 and 2020 were evaluated. Univariable and multivariable logistic regression was performed to determine the predictors of tertiary hyperparathyroidism. Graft and recipient outcomes were assessed using multivariable Cox regression. A separate multivariable Cox regression was performed to determine the effect of treatment strategies on outcomes.

resultsPT-tHPT, defined as elevated PTH (> 65 ng/L) and persistent hypercalcemia (> 2.60 mmol/L), was diagnosed in 14% of recipients. Risk factors for PT-tHPT included older age [odds ratio (OR) = 1.36,

conclusionPretransplant elevated calcium and PTH levels, older age and dialysis duration are associated with PT-tHPT. While PT-tHPT significantly affects graft and recipient survival, the treatment strategies did not affect survival.

Indexed as

CalcimimeticsFibroblast growth factor 23Graft survivalKidney transplantationMineral bone disorderParathyroidectomyParathyroid hormonePost-transplant tertiary hyperparathyroidismRisk factorsTreatment outcomes

Identifiers

PMID41607829
PMCPMC12836266

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.