ArticleFrontiers in veterinary science2025
Genome-wide selection analysis identifies genes associated with mandibular defects in Duolang sheep.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Brachycephaly is characterized by a conspicuously shortened craniofacial structure. While it is a defining trait in certain species such as Bulldogs, Persian cats, Niata cattle, Anglo-Nubian goats, and Middle White pigs, it may also represent a pathological condition. In Duolang sheep, brachycephaly is strikingly pronounced and may arise from distinct genetic and developmental mechanisms linked to breed history. This condition, often accompanied by mandibular prognathism, predisposes affected animals to health problems including brachycephalic airway obstruction syndrome, nasal blockage with dyspnea, and feeding difficulties. Duolang sheep, a dominant indigenous breed in southern Xinjiang, China, comprise approximately two million individuals, nearly 10% of which exhibit this heritable defect. Such a high prevalence poses a significant challenge to genetic improvement programs in local populations. Elucidating the genetic basis of this phenotype and identifying candidate genes is therefore essential. Methods: To characterize the craniofacial phenotype, we obtained X-ray measurements of maxillary length, mandibular length, and incisor angle. Affected sheep displayed significantly shorter maxillae and longer mandibles compared with controls ( Results: Candidate regions under strong selection were identified by Fst and Discussion: These findings provide new insights into the genetic basis of brachycephaly in Duolang sheep and offer strategies for genetic improvement, contributing to broader research on skeletal development and growth regulation in livestock.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.