Evidence map›Paper›PMID 41607945›Full record

ArticleFrontiers in veterinary science2025

Differential analysis of splenic immune indicators, transcriptomic profiles, and metabolomic features in pigs under liquid-solid feeding conditions.

Yangguang Liu, Cuiyun Zhu, Huibin Zhang, Fan Xie, Haibo Ye, Shiming Zhao, Qianqian Wang, Xianrui Zheng, Zongjun Yin, Xiaodong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yangguang LiuCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, China.
Cuiyun ZhuCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, China.
Huibin ZhangAnhui Provincial Key Laboratory of Livestock and Poultry Product Safety, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei, China.
Fan XieCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, China.
Haibo YeCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, China.
Shiming ZhaoCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, China.
Qianqian WangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, China.
Xianrui ZhengCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, China.
Zongjun YinCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, China.
Xiaodong ZhangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Fermented liquid feed (FLF) has been shown to improve feed efficiency and growth performance of pigs, however, its effects on porcine immune function remain poorly understood. Methods: In this study, transcriptomic, metabolomic, and ELISA-based approaches were employed to systematically evaluate the effects of fermented liquid feed on immune factor levels, splenic metabolic profiles, and gene expression in pigs. A total of 64 commercial pigs were randomly assigned to two groups, fed a basal diet group (CON) and a fermented liquid diet group (LFF), for a feeding period of 60 days. Results: The results showed that, compared with the CON group, the LFF group exhibited significantly higher serum concentrations of interleukin-6(IL-6, 767.88 ± 12.43 pg/ml), tumor necrosis factor-α(TNF-α 678.32 ± 15.37 pg/ml), complement C3(145.92±3.69 μg/ml), immunoglobulin A(IgA, 485.15 ± 9.13 μg/ml), and interferon-γ(IFN-γ 1966.76 ± 72.22 pg/ml). Meanwhile, transcriptome sequencing revealed that the expression levels of immune-related genes Discussion: In conclusion, our findings indicate that fermented liquid feed significantly enhances immune function in pigs, providing a theoretical basis for its scientific application and promotion in healthy farming of pigs.

Indexed as

fermented liquid feedimmunitymetabolomepigtranscriptome

Identifiers

PMID41607945
PMCPMC12836965

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.