ReviewCureus2025
Outcomes of Beinaglutide on Weight Loss in Patients With Diabetes or Obesity: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beinaglutide, a new short-acting glucagon-like peptide-1 (GLP-1) receptor agonist, has been investigated for use in patients with type 2 diabetes mellitus (T2DM) and obesity. This systematic review aims to assess the effectiveness of beinaglutide for weight loss and evaluate its safety profile in patients with T2DM or obesity. A systematic review search following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was performed across four databases for studies evaluating the weight loss effects of beinaglutide. A meta-analysis using SPSS program version 29 (IBM Corp., Armonk, NY) was conducted to analyze weight loss effects in T2DM or obesity populations. Nine studies (six randomized controlled trials, two prospective cohort studies, and one retrospective cohort study), comparing beinaglutide with other therapies such as metformin, insulin glargine, and lifestyle modifications, were included. A total of 1268 patients, with a mean age of 41.7 years (range: 25.4-53.3 years) and a mean follow-up of 47.6 weeks (range: 12-168 weeks), were included in this study. Meta-analysis for patients with obesity or T2DM showed weight reductions of 3.26 kg (95% CI: -4.03 to -2.49) and 6.52 kg (95% CI: -9.32 to -3.72), respectively. Adverse events (AEs) were observed in 382 (94.6%) participants receiving beinaglutide treatment (five studies). Beinaglutide demonstrated greater weight loss compared to placebo or active comparators but was associated with higher rates of AEs. Further long-term and comparative studies are needed to clarify its safety profile and potential advantages over current treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.