ReviewJournal of human immunity2026
The systemic effects of 22q11.2 deletion syndrome on immunity.
Review in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Second-tier genetics improves newborn screening accuracy for SCID and other T cell deficiencies.Journal of human immunity · 2026Article
- Heterozygous CECR2 variants support a distinct neurodevelopmental syndrome with features overlapping cat eye syndrome.HGG advances · 2026Article
- Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome.Journal of human immunity · 2026Article
- Toward a monogenic architecture of human infections: From 1996 to 2026.Journal of human immunity · 2026Review
- Expanding the scope of human immunology in theJournal of human immunity · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
22q11.2 deletion syndrome (22q11.2DS) affects about 1/2,150 individuals, causing complex and variably penetrant clinical problems. The clinical phenotypes evident at birth can include thymic hypoplasia, hypoparathyroidism, heart defects, and/or facial dysmorphism. Neurological issues including behavioral problems such as autism spectrum disorders and schizophrenia are evident at later postnatal periods. Thymic hypoplasia affects about 60-70% of patients, leading to T cell lymphopenias of varying severity. In rare cases, a congenital athymia occurs, necessitating a thymic implant. This review provides information regarding the causes and consequences of 22q11.2DS on thymic functions along with its broader impacts on the immune system. The affected immune cells include T, B, and mast cells. Patients with 22q11.2DS have more infectious, autoimmune, and allergic complications. Broader systemic changes including increased vascular permeability, a disrupted blood-brain barrier, and epigenetic alterations resulting from deletions on chromosome 22q11.2 affect many organ systems that can involve immune responses.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.