ArticleHealth science reports2026
Peripheral Blood Skin-Homing T Cells Define Immunological Endotypes in Atopic Dermatitis: A Case-Control Study in a Mexican Population.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Peripheral Blood Skin-Homing T Cells Define Immunological Endotypes in Atopic Dermatitis: A Case-Control Study in a Mexican Population.Health science reports · 2026Article
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Authors and funding
7 authors.
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Abstract
Background and Aims: Atopic dermatitis (AD) is a chronic inflammatory skin disease with marked immunological heterogeneity. T-cell subsets expressing CLA, CCR4, and CCR10 are involved in skin inflammation, but their frequency and expression patterns in AD remain poorly characterized. This study aimed to define distinct immunological endotypes of AD in the Mexican population by analyzing the frequency of CLA⁺ T cells expressing CCR4 and CCR10, along with their cytokine production profiles. Methods: Flow cytometry quantified CD4⁺ and CD8⁺ T cells in 47 Mexican AD patients, 15 healthy controls, and 16 allergic individuals. Principal component analysis and unsupervised clustering were used to identify immunological patterns. Results: Two AD endotypes were identified. Endotype 1 exhibited a higher frequency of CD4⁺CLA⁺ T cells (32.1% vs. 21.0%; Conclusion: AD presents distinct immunological endotypes characterized by specific T-cell profiles, which may inform personalized treatment strategies. This study provides insights into the immunological heterogeneity of AD in the Mexican population and underscores the need for population-specific approaches in disease characterization and management.
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