Evidence map›Paper›PMID 41608409›Full record

ArticleCJC pediatric and congenital heart disease2025

Pulmonary Artery Remodelling Assessed by Four-Dimensional Flow Magnetic Resonance Imaging in Pulmonary Arterial Hypertension and Atrial Septal Defect.

Estibaliz Valdeolmillos, Emmanuelle Fournier, Hichem Sakhi, Paul Vignaud, Marion Audié, Marc-Antoine Isorni, Bastien Provost, Florence Lecerf, Clément Batteux, Grégoire Albenque and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CJC pediatric and congenital heart disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Estibaliz ValdeolmillosDepartment of Congenital Heart Diseases, Reference Center for Complex Congenital Disease M3C, Rare Disease Ntework, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
Emmanuelle FournierDepartment of Congenital Heart Diseases, Reference Center for Complex Congenital Disease M3C, Rare Disease Ntework, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
Hichem SakhiDepartment of Congenital Heart Diseases, Reference Center for Complex Congenital Disease M3C, Rare Disease Ntework, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
Paul VignaudDepartment of Congenital Heart Diseases, Reference Center for Complex Congenital Disease M3C, Rare Disease Ntework, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
Marion AudiéDepartment of Congenital Heart Diseases, Reference Center for Complex Congenital Disease M3C, Rare Disease Ntework, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
Marc-Antoine IsorniDepartment of Radiology, Les Hôpitaux Paris Saint-Joseph et Marie Lannelongue, Le Plessis-Robinson, France.
Bastien ProvostDepartment of Congenital Heart Diseases, Reference Center for Complex Congenital Disease M3C, Rare Disease Ntework, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
Florence LecerfResearch and Innovation Department, Marie Lannelongue Hospital, Le Plessis-Robinson, France.
Clément BatteuxDepartment of Congenital Heart Diseases, Reference Center for Complex Congenital Disease M3C, Rare Disease Ntework, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
Grégoire AlbenqueDepartment of Congenital Heart Diseases, Reference Center for Complex Congenital Disease M3C, Rare Disease Ntework, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
Olivier SitbonParis-Saclay University, INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue, ERN-LUNG, Le Plessis-Robinson, France.
David MontaniParis-Saclay University, INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue, ERN-LUNG, Le Plessis-Robinson, France.
Xavier JaisParis-Saclay University, INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue, ERN-LUNG, Le Plessis-Robinson, France.
Laurent SavaleParis-Saclay University, INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue, ERN-LUNG, Le Plessis-Robinson, France.
Marc HumbertParis-Saclay University, INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue, ERN-LUNG, Le Plessis-Robinson, France.
Arshid AzarineParis-Saclay University, INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue, ERN-LUNG, Le Plessis-Robinson, France.
Sébastien HascoëtDepartment of Congenital Heart Diseases, Reference Center for Complex Congenital Disease M3C, Rare Disease Ntework, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pulmonary artery (PA) stiffness plays a significant role on right ventricular (RV) function, as evidenced in pulmonary arterial hypertension (PAH). In patients with atrial septal defect-related PAH (ASD-PAH), prognosis is dependent on RV function. We aimed to characterize PA remodelling and its relationship with RV function using 4-dimensional flow magnetic resonance imaging (4D flow MRI) in patients with ASD-PAH. Methods: We prospectively included 24 adults with ASD-PAH. They underwent 4D flow MRI and right heart catheterization within 24-48 hours. Remodelling of PA was analysed (stiffness, compliance, distensibility, elastance, and pulsatility) and PA vortex was evaluated. RV adaptation was measured by RV ejection fraction and RV-PA coupling. Results: The median age was 50 [41-55] years, and the median mean PA pressure and pulmonary vascular resistance were 50 [39-58] mm Hg and 8.0 [6.8-11.3] WU, respectively. Fourteen patients (58.3%) had RV dysfunction (RV ejection fraction <45%). All presented PA dilation (median main PA diameter: 42 [37-48] mm) and an increase in PA stiffness (10 [7.4-15.3]), whereas compliance and distensibility were decreased (2.1 [1.8-4.1] mm Conclusions: PA stiffness parameters characterized by 4D flow MRI were impaired in the population with ASD-PAH, and PA remodelling appears to be influenced by volumetric overload from the left-to-right shunt through the ASD.

Identifiers

PMID41608409
PMCPMC12835424

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.