Evidence map›Paper›PMID 41608424›Full record

ArticleFrontiers in medicine2025

Assessing the relationship between gout and the risk of cataract in community-dwelling older adults: mediation and moderation analysis.

Shuilian Chen, Chunxin Lai, Fulong Luo, Yongyi Niu, Yongjie Qin, Yanlei Chen, Zhuoting Zhu, Xianwen Shang, Xueli Zhang, Yu Huang and 1 more

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Shuilian ChenGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Chunxin LaiGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Fulong LuoGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Yongyi NiuGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Yongjie QinGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Yanlei ChenGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Zhuoting ZhuCentre for Eye Research Australia, Melbourne, VIC, Australia.
Xianwen ShangGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Xueli ZhangGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Yu HuangGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Hongyang ZhangGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to assess whether gout is a risk for cataract and identify important factors contributing to the association. Methods: A total of 381,402 individuals from the UK Biobank were enrolled at baseline (2006-2010). Cataract was ascertained using hospital inpatient and self-reported data until early 2021. Gout was determined by ICD-9, ICD-10, self-report, and medication at baseline. The Cox regression model was used to estimate the hazard ratio (HR) and 95% confidence intervals (CIs) for the risk of cataract. Results: The risk of cataract was significantly increased in patients with gout (HR, 1.69; 95% CI, 1.48-1.94; p < 0.001), and this association was attenuated but remained significant after additional adjusting for other covariates (HR, 1.14; 95% CI, 1.04-1.26; p = 0.006). In addition, we observed a significant interaction effect between gout and glucocorticoids (GCC) use for senile cataract (p = 0.04). In the sensitivity analysis, we stratified the population by sex, diabetes mellitus (DM), and GCC use. We noticed that gout remains a risk factor for cataract in both sexes and in patients with or without GCC use. Finally, we tested the mediation effect of GCC; we observed that 2.4% of the effect between gout and cataract and 3% of the effect between gout and senile cataract was mediated by GCC use. Conclusion: This cohort study found that gout was an independent risk factor for cataract, with a significant impact on senile cataract. GCC use modified the effect of gout on the development of senile cataract (interaction effect), thus prescribing GCC to patients with gout should be actively monitored for cataract development.

Indexed as

cataractcohort studyglucocorticoidsgoutmediation and moderation

Identifiers

PMID41608424
PMCPMC12836401

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.