Evidence map›Paper›PMID 41608482›Full record

ArticleWorld journal of orthopedics2026

Mapping awareness and application of orthobiologics among orthopaedic professionals: A cross-sectional study.

Madhan Jeyaraman, Naveen Jeyaraman, Swaminathan Ramasubramanian, Arulkumar Nallakumarasamy, Viji Devanand, Sathish Muthu

Abstract read
In one paragraph

Article in World journal of orthopedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Madhan JeyaramanDepartment of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India.
Naveen JeyaramanDepartment of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India.
Swaminathan RamasubramanianDepartment of Regenerative Medicine, Agathisha Institute of Stemcell and Regenerative Medicine, Chennai 600030, Tamil Nadu, India. swaminathan.ramasubramanian@outlook.com.
Arulkumar NallakumarasamyDepartment of Regenerative Medicine, Agathisha Institute of Stemcell and Regenerative Medicine, Chennai 600030, Tamil Nadu, India.
Viji DevanandDepartment of Physiology, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai 600044, Tamil Nadu, India.
Sathish MuthuDepartment of Orthopaedics, Orthopaedic Research Group, Coimbatore 641045, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOrthobiologics-biological substances like platelet-rich plasma (PRP), bone marrow aspirate concentrate, and stem cells-are increasingly used in musculoskeletal care to promote tissue repair and reduce reliance on invasive surgery. Despite global momentum, India's clinical adoption remains underexplored.

aimTo inform education, policy, and resource allocation for the safe and effective adoption of orthobiologics in musculoskeletal care.

methodsA cross-sectional electronic survey was conducted from January to March 2025 among orthopaedic surgeons, academicians, and trainees across India. The questionnaire assessed demographics, knowledge of orthobiologics, attitudes toward training and subspecialization, usage trends, regulatory awareness, and perceived barriers. Data were analyzed using descriptive statistics and

resultsA total of 1280 valid responses were collected. Awareness of orthobiologics was high (97%), with PRP being the most familiar and widely used (80%). Formal training was reported by only 31%, though 85% showed interest in structured education, and 68% supported orthobiologics as a subspecialty. Satisfaction with clinical outcomes averaged 6.5 ± 2.3 out of 10 points. Barriers included high treatment cost (64%), poor patient awareness (90%), and limited access to biologics labs (18%). Regulatory understanding was moderate, with academic-affiliated clinicians more informed about stem cell guidelines.

conclusionIndian orthopaedic professionals demonstrate strong awareness and optimism toward orthobiologics, but widespread gaps in training, infrastructure, and regulation hinder broader adoption. Strategic investments in education, standardized protocols, and accessible facilities are essential to support safe and evidence-driven integration of regenerative therapies into clinical practice.

Indexed as

Bone marrow aspirate concentrateOrthobiologicsOrthopaedicsPlatelet-rich plasmaRegenerative orthopaedics

Identifiers

PMID41608482
PMCPMC12836188

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.