ArticleFrontiers in nutrition2025
Overlap between body composition abnormalities and sex-specific prognostication in decompensated cirrhosis.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: We aimed to demonstrate distinct body composition (BC) profiles stratified by sex and clarify their joint effects on long-term mortality in a retrospective cohort of inpatients. Methods: Various BC parameters annotated on computed tomography (CT) images at the third lumbar vertebra were used to define sarcopenia, myosteatosis, low subcutaneous adiposity, and high visceral adiposity. These categories were constructed using sex-specific, outcome-based cutoffs in a prerequisite manner. Results: Among 519 patients hospitalized for acute decompensating episodes, the median age was 64.0 years, with a slight female predominance (51.6%). Among the female patients, high visceral adiposity was the most prevalent single BC abnormality (38.4%), while the most common overlapping phenotype was myosteatosis occurring concurrently with high visceral adiposity (9.7%). Among the male patients, high visceral adiposity also showed the highest prevalence (74.9%), while the most common overlapping phenotype was sarcopenia occurring concurrently with low subcutaneous adiposity (15.1%). Considering their jointly negative impact, the female patients experiencing three BC abnormalities had the lowest survival rate (33.3%, log-rank test: Conclusion: In conclusion, sex-specific variations in BC profiles were observed among the patients with decompensated cirrhosis.
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