ReviewStroke (Hoboken, N.J.)2025
Endothelial Cell Genetics in Carotid Artery Atherosclerosis and Intracranial Atherosclerosis: A Systematic Review.
Review in Stroke (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- MicroRNA Profiling of the Pathophysiological Mechanisms Underlying Carotid Atherosclerosis Progression.Biomolecules · 2026Review
- Impact of age on clinical outcomes after endovascular therapy for large ischemic stroke.Journal of neurology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemic stroke, a leading cause of global mortality, is often linked to large-artery atherosclerosis, including carotid artery atherosclerotic disease and intracranial atherosclerotic disease. Endothelial cells, which are central to vascular homeostasis, are pivotal in the pathophysiology of these conditions. This systematic review explores the genetic and molecular characteristics of endothelial cells in carotid artery atherosclerotic disease and intracranial atherosclerotic disease, emphasizing their roles in disease progression and potential therapeutic applications. The findings reveal significant differences in the underlying mechanisms of carotid artery atherosclerotic disease and intracranial atherosclerotic disease, reflecting the unique genetic, inflammatory, and vascular remodeling processes associated with each condition. Endovascular biopsy is examined as a minimally invasive method for isolating endothelial cells, providing a valuable tool for studying disease-specific pathways and advancing precision medicine, although improvements in technique and consistency are still required. This review underscores the importance of integrating advanced genetic and transcriptomic analyses with refined biopsy methods to better understand the molecular drivers of cerebrovascular atherosclerosis. These advancements are critical for identifying novel therapeutic targets, improving diagnostic accuracy, and ultimately enhancing patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.