ArticleInvestigative ophthalmology & visual science2026
Retinal and Choriocapillaris Thickness and Age in Macaques in Development and Aging.
Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Aging of Nonhuman Primate Eyes Is Sexually Dimorphic.Investigative ophthalmology & visual science · 2026Article
- Age-Related Neurovascular Dysfunction in the Retina and Potential Pathogenic Mechanisms.Investigative ophthalmology & visual science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Purpose: Nonhuman primates (NHPs) serve as valuable models for human retinal and choroidal diseases related with development and aging. This study aimed to investigate the association among age and thickness of the retina, RPE, and choriocapillaris in cynomolgus macaques. Association of age with choriocapillaris was examined in postmortem human samples. Methods: Optical coherence tomography images were obtained from 543 eyes from 285 macaques aged 0.78 to 22.4 years. The association between age and thickness of retinal and subretinal layers were examined using piecewise linear mixed effects models. Choriocapillaris thickness was assessed microscopically in postmortem human globes from 24 individuals aged 11 to 82 years. Results: Before age 4 years (equivalent to 12 years in humans), total retinal thickness and ganglion cell layer, inner nuclear layer, and parafoveal outer nuclear layer thickness were positively associated with age, whereas after age 4 years, thicknesses of these layers were negatively associated. Age was negatively associated with retinal nerve fiber layer and foveal outer nuclear layer thickness, but positively with thicknesses of RPE/Bruch's membrane and choriocapillaris layers throughout the entire age range. Analysis of postmortem human specimens demonstrated a positive correlation between choriocapillaris diameter and age. Conclusions: Cynomolgus macaques undergo thickening of multiple retinal layers through their juvenile stage. Afterward, macaques undergo thinning of multiple retinal layers with age, suggesting aging-related changes. The increase in choriocapillaris thickness with age in both macaques and humans suggest remodeling due to aging. Cynomolgus macaques represent a valuable NHP model for studying developmental- and aging-related retinal/subretinal changes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.