Evidence map›Paper›PMID 41609276›Full record

ArticleJACC. Advances2026

Metabolic Signatures of Air Pollution and Major Adverse Cardiovascular Events in Patients Undergoing Cardiac Catheterization.

Chang Liu, Duan Wang, Zhihao Jin, Yi-An Ko, Howard H Chang, Ayman A Alkhoder, Nisreen Haroun, Yan V Sun, Vilinh Tran, Dean P Jones and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chang LiuDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
Duan WangGangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
Zhihao JinGangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
Yi-An KoDepartment of Biostatistics, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
Howard H ChangDepartment of Biostatistics, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
Ayman A AlkhoderDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Nisreen HarounDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Yan V SunDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
Vilinh TranDepartment of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Dean P JonesDepartment of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Arshed A QuyyumiDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Donghai LiangDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA; Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, Georgia, USA. Electronic address: donghai.liang@emory.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAir pollution is an environmental risk factor for coronary artery disease. The molecular mechanisms linking fine particulate matter (PM

objectivesThe objective of the study was to investigate the molecular pathways linking air pollution to cardiovascular risk by analyzing the metabolome, focusing on the mediating role of metabolites.

methodsWe analyzed data from the Emory Cardiovascular Biobank, including 244 participants with metabolomic profiling, air pollution data, and a median follow-up of 9.8 (IQR: 4.6-12.2) years. Metabolomic profiling was performed via liquid chromatography-high- resolution mass spectrometry, and pollutants (PM

resultsPer IQR higher in CO was associated with a 24% higher risk in MACE (subdistribution HR [sHR]: 1.24; 95% CI: 1.03-1.49; P = 0.02), whereas PM

conclusionsAir pollution links to metabolic changes that contribute to cardiovascular disease progression and MACE.

Indexed as

air pollutionCOMACEMWASNOxPM(2.5)

Identifiers

PMID41609276
PMCPMC12869874

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.