Trial reportmSystems2026
Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling.
Yingmeng Li, Qiong Li, Keyu Quan, Yong Xie, Ni Yang, Teng Ma, Longjin Zheng, Wei Zhou, Yalin Li, Hao Jin and 7 more
Abstract readRandomized Controlled Trial
In one paragraphTrial report in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
17 authors.
Yingmeng Li *Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.ORCID 0000-0003-3377-2448 Qiong Li *State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China.ORCID 0000-0003-1428-8626 Keyu Quan *Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.ORCID 0000-0001-6058-8617 Yong Xie *Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.ORCID 0000-0002-5290-5579 Ni YangState Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China.
Teng MaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Longjin ZhengState Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China.
Wei ZhouState Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China.
Yalin LiInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Hao JinInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Zhihong SunInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.ORCID 0000-0002-7605-2048 Yongfu ChenInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Lai-Yu KwokInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Nonghua LuDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.ORCID 0000-0003-4373-551X Weifeng ZhuState Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China.ORCID 0000-0003-0679-0691 Wenjun LiuState Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China.ORCID 0000-0002-1561-3796 Heping ZhangInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.ORCID 0000-0002-4140-7486 Funding
National Key Research and Development Program of China No. 2022YFD2100700National Natural Science Foundation of China No. U22A20540the China National Postdoctoral Program for Innovative Talents BX20250337the Earmarked Fund for China Agriculture Research System CARS-36the Inner Mongolia Autonomous Region Science and Technology Leading Talent Team Project No.2022LJRC0003
6 · The paper itselfAbstract
Proton pump inhibitors (PPIs) are standard therapy for gastroesophageal reflux disease (GERD), but long-term use causes dysbiosis, gastrointestinal side effects, and symptom relapse after discontinuation. Probiotics may offer adjunctive benefits by modulating the gut ecosystem. The study aimed to evaluate the efficacy of a multi-strain probiotic (Lihuo) with rabeprazole in GERD and its impact on gut microbiota and metabolome. A randomized, double-blind, placebo-controlled trial was conducted in 120 GERD patients assigned to receive rabeprazole with either Lihuo (
Indexed as
Gastroesophageal RefluxGastrointestinal MicrobiomeMetabolomeProbioticsAdultDouble-Blind MethodFemaleHumansMaleMetabolomicsMiddle AgedProton Pump InhibitorsRabeprazoleTreatment OutcomeProton Pump InhibitorsRabeprazolegastroesophageal reflux diseasemicrobiome-host interactionmulti-omicsproton pump inhibitorrabeprazolereflux disease questionnaireshort-chain fatty acids
Identifiers
PMID41609355
PMCPMC12911400
What Socratic holds
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