Trial reportJournal of the National Cancer Institute2026
Effects of a structured exercise program on motivational outcomes in patients with colon cancer.
Trial report in Journal of the National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00819208 (A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients With High-Risk Stage II or Stage III Colon Cancer), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients With High-Risk Stage II or Stage III Colon Cancer: A Randomized Controlled Trial
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Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
backgroundColon Health and Life-Long Exercise Change (CHALLENGE) was the first phase 3 trial to examine the effects of exercise on cancer-related survival and, therefore, required a substantial and sustained increase in moderate-to-vigorous physical activity (MVPA) that had not been achieved in previous trials. Here, we report the effects of the intervention on the social cognitive beliefs that were targeted to achieve long-term exercise behavior change.
methodsPatients with resected colon cancer who had completed chemotherapy were randomized to health education materials (HEM) or a structured exercise program (SEP) consisting of 48 behavioral support sessions delivered over a 3-year period. Social cognitive constructs from the Theory of Planned Behavior were assessed by single items using 5-point scales at baseline and every 6 months during the 3-year intervention. Regression models for repeated measurements were used to estimate the least square means and robust standard errors (SEs) for each randomized group at each time point.
resultsBetween 2009 and 2024, 889 patients were randomized to SEP (n = 445) or HEM (n = 444). SEP compared to HEM reported significantly more favorable social cognitive beliefs about exercise at almost all time points. Average intervention effects (AIE) across the 3-year intervention favored SEP for perceived benefit (AIE = 0.29; P < .001), enjoyment (AIE = 0.40; P < .001), difficulty (AIE = -0.18; P = .003), confidence (AIE = 0.28; P < .001), support (AIE = 0.59; P < .001), motivation (AIE = 0.47; P < .001), opportunity (AIE = 0.31; P < .001), and planning (AIE = 0.82; P < .001). All social cognitive variables were significantly associated with self-reported MVPA at all time points.
conclusionsThe SEP intervention in the CHALLENGE trial successfully targeted the social cognitive beliefs that were associated with sustained MVPA. NCT00819208.
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