Evidence map›Paper›PMID 41609436›Full record

ArticleThe FEBS journal2026

Metabolic pathways fuelling devil facial tumour diseases.

Anne-Lise Gérard, Florence Pirard, Caitlin Vanbeek, Antoine M Dujon, Aaron G Schultz, Rodrigo K Hamede, Hannah V Siddle, Frédéric Thomas, Matthew McKenzie, Mark D Ziemann and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anne-Lise GérardSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds, Australia.ORCID https://orcid.org/0000-0001-9495-2894
Florence PirardSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds, Australia.ORCID https://orcid.org/0009-0007-8307-3430
Caitlin VanbeekSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds, Australia.
Antoine M DujonSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds, Australia.ORCID https://orcid.org/0000-0002-1579-9156
Aaron G SchultzSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds, Australia.ORCID https://orcid.org/0000-0002-7333-7646
Rodrigo K HamedeSchool of Natural Sciences, University of Tasmania, Hobart, Australia.ORCID https://orcid.org/0000-0003-1526-225X
Hannah V SiddleQueensland Alliance for Agriculture & Food Innovation, The University of Queensland, Brisbane, Australia.ORCID https://orcid.org/0000-0003-2906-4385
Frédéric ThomasCentre for Ecological and Evolutionary Cancer Research, MIVEGEC, University of Montpellier, CNRS, IRD, Occitania, France.ORCID https://orcid.org/0000-0003-2238-1978
Matthew McKenzieSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds, Australia.ORCID https://orcid.org/0000-0001-7508-1800
Mark D ZiemannSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds, Australia.ORCID https://orcid.org/0000-0002-7688-6974
Beata UjvariSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds, Australia.ORCID https://orcid.org/0000-0003-2391-2988

Funding

Agence Nationale de la Recherche, TRANSCAN ANR--18--CE35--0009Australian Research Council DE170101116Australian Research Council DP230100162Australian Research Council LP170101105Centre National de la Recherche Scientifique, International Research ProjectHoffmann FamilyMorris Animal Foundation D19ZO--413NCRIS-funded Australian Research Data Commons (ARDC), Nectar Research CloudSave The Tasmanian Devil Eric Guiler Research FundsSchool of Life and Environmental Sciences, Deakin UniversityVictorian Operational Infrastructure Support Program
6 · The paper itself

Abstract

Devil Facial Tumour Diseases (DFTD), threatening Tasmanian devils, consist of two distinct transmissible cancers, DFT1 and DFT2, with differing origins and geographic spread. We investigated the metabolic differences between DFT1 and DFT2, examining cell viability, metabolic outputs, and bulk gene expression. Using both DFT1 and DFT2 cell lines and biopsies, we found that glycolysis, oxidative phosphorylation, glutamate metabolism, and fatty acid synthesis are all essential for the survival of both tumour types. However, DFT2 exhibited higher rates of glycolysis and lactate generation compared to DFT1. This coincided with elevated ATP production, cholesterol biosynthesis, and ROS generation, as well as an increased reliance on fatty acid metabolism. Furthermore, DFT2 is less metabolically adaptable than DFT1, being unable to switch to oxidative phosphorylation as DFT1 can when required. These metabolic changes in DFT2, in conjunction with its higher growth rate, suggest a more aggressive cancer phenotype than DFT1. Our findings highlight distinct metabolic adaptations in DFT2 that may contribute to its competitive advantage.

Indexed as

Facial NeoplasmsMarsupialiaMetabolic Networks and PathwaysAnimalsCell Line, TumorCholesterolFatty AcidsGlycolysisHumansMetabolic ReprogrammingOxidative PhosphorylationReactive Oxygen SpeciesCholesterolFatty AcidsReactive Oxygen Speciescancercholesterol biosynthesisglycolysispathway enrichmentreactive oxygen speciestranscriptomics

Identifiers

PMID41609436
PMCPMC13370695

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.