Evidence map›Paper›PMID 41609487›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Conversion of Transplanted Mature Hepatocytes into Afp

Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Conversion of Transplanted Mature Hepatocytes into AfpAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ting FangInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Chao YangInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Hua QiuInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Yuan DuInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Xicheng WangInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Yuting LiInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Mingyang XuInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Changcheng LiuInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Xiuhua LiInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Na GuoInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Jun ShiInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Wencheng ZhangInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.
Zhiying HeInstitute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiovascular Diseases, School of Life Sciences and Technology, Shanghai East Hospital, Tongji University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0002-0087-2277

Funding

National Natural Science Foundation of China 82270638National Natural Science Foundation of China 82300718National Natural Science Foundation of China 82301904National Natural Science Foundation of China 82471592Peak Disciplines (Type IV) of Institutions of Higher Learning in ShanghaiShanghai Clinical Research Center for Cell Therapy 23J41900100Shanghai Engineering Research Center of Stem Cells Translational Medicine 20DZ2255100
6 · The paper itself

Abstract

Hepatocyte transplantation effectively treats liver failure, yet the regenerative mechanisms driven by engrafted mature hepatocytes remain elusive. Through integrated serial transplantation, lineage tracing, single-cell RNA sequencing (scRNA-seq), and single-cell transposase-accessible chromatin sequencing (scATAC-seq), we show that donor hepatocytes convert into transitional, alpha-fetoprotein-positive reprogrammed hepatocytes (Afp

Indexed as

alpha-FetoproteinsCellular ReprogrammingHepatocytesLiverLiver RegenerationAnimalsCell DifferentiationCell ProliferationMaleMicealpha-Fetoproteinsalpha‐fetoprotein‐positive reprogrammed hepatocytes (Afp+ rHeps)hepatocyte transplantationliver regenerationPPARγ pathwayTNF‐α/AP‐1 signaling

Identifiers

PMID41609487
PMCPMC13042875

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.