ReviewCurrent atherosclerosis reports2026
Pleiotropic Effects of Statins: Focus on Endothelial Function, Plaque Stability and Thrombosis (Part II).
Review in Current atherosclerosis reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mechanisms and Predisposing Conditions for Statin-Induced New-Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects.Endocrinology, diabetes & metabolism · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewStatins are the first-line therapy for lipid-lowering and cardiovascular (CV) disease (CVD) prevention. Increasing evidence supports additional cardioprotective properties of statins through pleiotropic effects unrelated to lipid modulation. We aimed to discuss the pleiotropic effects of statins and their relevance to clinical outcomes in 2 reviews: Part I focuses on anti-inflammatory, antioxidant and immunomodulatory effects of statins, whereas Part II on statin-induced endothelial function improvement, plaque stabilization and anti-thrombotic effects. Part II also includes a clinical applications and future directions section. RECENT
findingsA literature search was conducted in Embase, Scopus, web of science, PubMed and Cochrane Library databases for experimental and clinical studies investigating the effects of statins on endothelial repair, plaque stability and thrombosis biomarkers. Statins were found to modulate immune cell phenotypes and endothelial repair pathways, as well as enhance plaque stability, inhibit thrombus formation and fibrin clot characteristics independent of lipids. Meta-analyses implicate these pleiotropic actions of statins with reduced CV events. Statins offer cardioprotection through several pleiotropic pathways distinct from lipid-lowering. To maximize clinical benefits, statins’ therapeutic potential beyond CVD should be further explored via non-lipid mechanisms. An in-depth knowledge of statins’ pleiotropic effects may uncover novel preventive strategies and therapeutic applications.
Indexed as
Identifiers
41609928What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.