Evidence map›Paper›PMID 41610132›Full record

ArticlePloS one2026

Genetic predisposition to elevated BMI and adult asthma phenotypes in a Japanese population.

Yohei Yatagai, Hisayuki Oshima, Yu Abe, Haruna Kitazawa, Hironori Masuko, Takashi Naito, Takefumi Saito, Tomomitsu Hirota, Mayumi Tamari, Emiko Noguchi and 2 more

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Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yohei YatagaiDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-4029-8222
Hisayuki OshimaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Yu AbeDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Haruna KitazawaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Hironori MasukoDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Takashi NaitoTsukuba Medical Center, Ibaraki, Japan.
Takefumi SaitoNational Hospital Organization Ibaraki Higashi National Hospital, Ibaraki, Japan.
Tomomitsu HirotaDivision of Molecular Genetics, The Jikei University School of Medicine, Research Center for Medical Science.
Mayumi TamariDivision of Molecular Genetics, The Jikei University School of Medicine, Research Center for Medical Science.
Emiko NoguchiDepartment of Medical Genetics, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Tohru SakamotoTsukuba Memorial Hospital, Tsukuba, Japan.
Nobuyuki HizawaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a well-established risk factor for asthma, with genetic factors influencing both conditions. This study investigates the impact of genetic predisposition to increased body mass index (BMI) on adult asthma phenotypes. We recruited 1532 non-asthmatic healthy individuals and 779 adult asthma patients to assess the relationship between BMI-related genetic risk scores (BMI-GRS) and asthma. Among the 85 single nucleotide polymorphisms (SNPs) previously associated with BMI in Japanese populations, significant associations with BMI were confirmed for 6 SNPs in the healthy individuals. Using these, BMI-GRS was calculated for both groups. While asthma patients had higher BMI than healthy individuals (p = 0.004), no significant difference in BMI-GRS was observed between the groups (p = 0.56). A cluster analysis identified six distinct phenotypes of adult asthma patients: two overweight/obese clusters (one with elevated BMI-GRS, one without) and four non-obese clusters (with one showing significantly elevated BMI-GRS). This study demonstrates a genetic heterogeneity in the phenotype of adult asthma among a Japanese population, showing that genetic variants associated with BMI contribute to specific subtypes of asthma. Prospective longitudinal studies are essential to delineate the interactions between genetic predisposition, elevated BMI, subsequent changes in adiposity, and the evolution of asthma phenotypes, which would facilitate the development of mechanism-based therapeutic strategies tailored to genetically-defined patient subgroups.

Indexed as

AsthmaBody Mass IndexGenetic Predisposition to DiseaseObesityAdultAgedCase-Control StudiesEast Asian PeopleFemaleHumansJapanMaleMiddle AgedPhenotypePolymorphism, Single NucleotideRisk Factors

Identifiers

PMID41610132
PMCPMC12854457

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.