Evidence map›Paper›PMID 41610310›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

The FOXC2-LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma.

Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. RNA splicing in health and disease.Molecular biomedicine · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiaxi YaoDepartment of Urology, The First Hospital of China Medical University, Shenyang, P. R. China.
Tong XuDepartment of Cell Biology, Key Laboratory of Cell Biology, National Health Commission of the PRC and Key Laboratory of Medical Cell Biology, Ministry of Education of the PRC, China Medical University, Shenyang, P. R. China.
Chengyuan WangDepartment of Urology, The First Hospital of China Medical University, Shenyang, P. R. China.
Chenyuan WangDepartment of Urology, The First Hospital of China Medical University, Shenyang, P. R. China.
Junfeng XieDepartment of Urology, The First Hospital of China Medical University, Shenyang, P. R. China.
Rui ZhengKey Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, Health Sciences Institute of China Medical University, Shenyang, P. R. China.
Ke WangDepartment of Urology, The First Hospital of China Medical University, Shenyang, P. R. China.
Xingzuo JiangDepartment of Urology, The First Hospital of China Medical University, Shenyang, P. R. China.
Zewei HuDepartment of Urology, The First Hospital of China Medical University, Shenyang, P. R. China.
Hongwei JingDepartment of Urology, The First Hospital of China Medical University, Shenyang, P. R. China.
Lin LiDepartment of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, P. R. China.
Tao LiuDepartment of Urology, The First Hospital of China Medical University, Shenyang, P. R. China.ORCID https://orcid.org/0000-0002-3044-8813

Funding

National Key R&D Program of China 2023YFC2507000National Natural Science Foundation of China 82573157Science and Technology Planning Project of Liaoning Province of China 2023JH2/20200090Shenyang Science and Technology Plan Project 24-214-3-21
6 · The paper itself

Abstract

The aggressive metastatic propensity of advanced clear cell renal cell carcinoma (ccRCC) originates from intratumoral heterogeneity. Through integrated single-cell and spatial multi-omics profiling, we identified a FOXC2

Indexed as

Carcinoma, Renal CellForkhead Transcription FactorsKidney NeoplasmsLamininAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceNeoplasm MetastasisNeovascularization, PathologicForkhead Transcription FactorsLamininmesenchyme fork head 1 proteinclear cell renal cell carcinomaFOXC2metastatic microenvironmentsingle‐cell multi‐omicsvasculogenic mimicry

Identifiers

PMID41610310
PMCPMC13067797

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.