ArticleBMC infectious diseases2026
Association between prothrombin time activity and short-term outcomes in patients with infective endocarditis.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoagulopathy, a frequent complication of infectious diseases, is strongly associated with adverse clinical outcomes. This study aimed to investigate the prognostic value of prothrombin time activity (PTA) in patients with infective endocarditis (IE).
methodsA total of 1,533 IE patients were stratified into four groups based on quartiles of PTA at admission: 1) < 73% (n = 366); 2) 73%-83% (n = 381); 3) 84%-92% (n = 370); and 4) ≥ 93% (n = 416). Receiver operating characteristic (ROC) analysis was used to identify the optimal PTA cut-off for predicting in-hospital mortality. Multivariable regression and subgroup analyses were conducted to assess the association between PTA and 6-month mortality.
resultsThe in-hospital mortality was higher in IE patients with lower PTA (15.8% vs. 5.8% vs. 4.6% vs. 2.9%; P < 0.001). PTA was independently associated with in-hospital death (odds ratio: 0.98; 95% CI: 0.97-0.99; P < 0.001). ROC curve analysis identified 78% as the optimal PTA cut-off value for predicting in-hospital mortality, with a sensitivity of 67.8% and specificity of 66.1% (AUC: 0.704; P < 0.001). In multivariable Cox regression analysis, PTA < 78% was an independent predictor of 6-month mortality, with a 2.27-fold increased risk after adjusting for potential confounders (95% CI: 1.63-3.17; P = 0.025). The predictive performance of PTA was robust across subgroups stratified by infection site, disease severity, and organ dysfunction.
conclusionPTA < 78% at admission is an independent predictor of poor short-term outcomes in patients with IE. This novel finding highlights the importance of coagulation assessment in IE and facilitates early risk stratification in IE management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.