Evidence map›Paper›PMID 41612402›Full record

ReviewMolecular cancer2026

Platinum-based functional nanomaterials: mechanisms and therapeutic strategies in cancer radiotherapy sensitization.

Yuanchao Cheng, Yakui Mou, Hanrui Wang, Hui Shen, Yue Hu, Xiaoyu Song, Mingjun Zhang, Yao Wang, Wanchen Liu, Ting Yang and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Current Perspectives on Radiosensitizers in Cancer Radiotherapy.International journal of nanomedicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuanchao Cheng *Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China.
Yakui Mou *Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China.
Hanrui Wang *Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China.
Hui ShenDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China.
Yue HuDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China.
Xiaoyu SongDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China.
Mingjun ZhangDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China.
Yao WangDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China.
Wanchen LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China.
Ting YangDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China.
Chao RenDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China. renchaotg@126.com.
Miao YanDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China. yanmiao@mail.ustc.edu.cn.
Xicheng SongDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, No.20, East Road, Zhifu District, Yantai, 264000, China. drxchsong@163.com.

Funding

China Postdoctoral Science Foundation No. 2024M762728Key Technology Research and Development Program of Shandong Province Competitive Innovation Platform Project: no. 2022CXPT023 and no. 2024CXPT091National Natural Science Foundation of China No. 82403926Natural Science Foundation of Shandong Province No. ZR2024QH477Taishan Scholar Project of Shandong Province No. tstp20250512 and no. tsqn202312392
6 · The paper itself

Abstract

Radiotherapy (RT) is an important treatment option for cancer. However, its efficacy is limited by tumor radioresistance caused by hypoxic microenvironments, overactivated DNA damage repair mechanisms in tumor cells, and unavoidable radiation-induced injury to surrounding normal tissues. In recent years, platinum-based functional nanomaterials (PFNs) have emerged as promising radiosensitizers because of their remarkable photoelectric attenuation characteristics and unique chemical and biological properties. Considerable attention has been devoted to elucidating the mechanisms by which PFNs enhance radiosensitivity and to optimizing their design for improved targeting accuracy and radiosensitization efficiency. In this review, we systematically summarize the radiosensitization mechanisms mediated by PFNs, exploring their principles from physical, biological, and biochemical perspectives. We also discuss common strategies for designing radiosensitizing PFNs, review recent advances in their application for tumor RT sensitization, and highlight their clinical potential and current challenges. This review provides a reference for the further development and clinical translation of PFNs in RT.

Indexed as

NanostructuresNeoplasmsPlatinumRadiation-Sensitizing AgentsRadiation ToleranceAnimalsHumansPlatinumRadiation-Sensitizing AgentsCancerPlatinum-based functional nanomaterialsRadiosensitizationRadiotherapy

Identifiers

PMID41612402
PMCPMC12853762

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.