Tailoring bone microenvironment with 2D layered materials.

Shengchang Zhang, Huaijuan Zhou, Yao Zhou, Jinhua Li, Jiadong Zhou

Abstract readReview

In one paragraph

Review in Fundamental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shengchang ZhangSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.

Huaijuan ZhouAdvanced Research Institute of Multidisciplinary Sciences, Beijing Institute of Technology, Beijing 100081, China.

Yao ZhouAdvanced Research Institute of Multidisciplinary Sciences, Beijing Institute of Technology, Beijing 100081, China.

Jinhua LiSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.

Jiadong ZhouCentre for Quantum Physics, Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE), School of Physics, Beijing Institute of Technology, Beijing 100081, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bone repair niche, including the physiological and pathological microenvironment, is a complex system that interferes with various cellular/noncellular activities. Thus, a rational perspective of designing tunable biomaterials with the modulation of the bone microenvironment is in high demand in pre/clinical practice for the management of refractory bone defects in combination with severe bone diseases. Two-dimensional (2D) layered materials are emerging biomaterials for bone microenvironment engineering because of their inherent biocompatibility, osteo-inductivity, osteo-conductivity, optical properties, enzyme mimetics, and mechanical properties. In this study, we focus on the latest advances in developing 2D layered materials in bone regeneration, bone cancer therapies, bone-related infections eradication, and articular cartilage repair. In addition, the specific action mechanisms and design regimens of 2D-layered material-based nanoplatforms are clarified. Finally, the current challenges are discussed, and the key inspirations for further broadening the pre/clinical applications of 2D layered materials in orthopedic disorder therapy are proposed.

Indexed as

2D layered materialsBone microenvironment engineeringBone repair and regenerationStimuli-responsive strategiesTherapeutic platforms

Identifiers

PMID41613439

DOI10.1016/j.fmre.2024.02.005

PMCPMC12848175

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.