ReviewBiophysical reviews2025
Microelectrode-based approaches for studying cholinergic neuromuscular transmission.
Review in Biophysical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Despite more than a century of research into the neuromuscular junction, it still remains a widely used experimental model for studying molecular mechanisms of synaptic transmission in various physiological and pathological conditions, as well as for testing different pharmacological agents. One of the generally accepted methodologies for achieving these goals is electrophysiological recordings using microelectrode techniques. Application of extracellular microelectrodes makes it possible to precisely evaluate the parameters of presynaptic action potential and its coupling with evoked exocytotic event. The use of intracellular microelectrodes allows the measurements of a resting membrane potential, amplitude-temporal parameters of evoked and spontaneous postsynaptic potentials, which depend on both neurotransmitter release and the postsynaptic membrane sensitivity to neurotransmitter. A voltage-clamp technique with two intracellular microelectrodes is the best option to access postsynaptic currents for characterization of both quantal content and functioning receptor-channel complexes within the end-plate region. To apply all of the above microelectrode approaches under conditions of motor nerve stimulation, an immobilization of neuromuscular preparations is necessary. Skeletal muscle paralysis can be accomplished by decreasing neurotransmitter release (via lowering extracellular Ca
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