ReviewBiophysical reviews2025
Antioxidant evolution of fibrinogen: a crucial role of methionines.
Review in Biophysical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review aims to provide evidence that the fibrinogen-like structures of invertebrates (on the example of the intracellular coagulation protein coagulogen from horseshoe crabs) and fibrinogen of vertebrates (such as lampreys, which are among the most primitive extant vertebrates, as well as higher-ordered animals on the phylogenetic evolutionary scale, such as chickens and humans) reflect their methionine-dependent adaptation to the steady-state level of reactive oxygen species (ROS). Since methionine residues disposed in primary structure of proteins may serve as ROS interceptors, the absence of methionines in the coagulogen structure suggests that it is not subject to ROS attack in the same extent as vertebrate extracellular fibrinogen. The structures of vertebrate fibrinogens (such as the central E-nodule composed of the NH
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.