Evidence mapPaperPMID 41614070Full record

ArticleFrontiers in pharmacology2025

High glucose-induced PLCG1 histone acetylation to promote ferroptosis by LAMP2A/HSPA8 in a diabetic nephropathy model.

Jun Ge, Zhenzhen Wang, Ting Xu, Ruifeng Jiang, Xuefeng Zhang

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jun GeDepartment of Nephrology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.
Zhenzhen WangDepartment of Pharmacy, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.
Ting XuDepartment of Pharmacy, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.
Ruifeng JiangDepartment of Nephrology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.
Xuefeng ZhangDepartment of Pharmacy, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is one of the most prevalent microvascular complications of diabetes mellitus. In the present study, the effects of PLCG1 DN, as well as its underlying molecular mechanisms associated with ferroptosis, were investigated. Single-cell RNA sequencing data and bioinformatic analyses were employed to support these experimental findings. For

Indexed as

diabetic nephropathyferroptosishistone acetylationPLCG1treatment

Identifiers

PMID41614070
PMCPMC12847005

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.